literature

HPV mutation literature information.

Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain.

PMID: 35115618 2022 Scientific reports

Abstract: The aim of this work was to evaluate, with an in silico approach, employing molecular dynamics simulation and protein-protein docking, the interaction of the intragenic variants E-G350 (L83V), E-C188/G350 (E29Q/L83V), E-A176/G350 (D25N/L83V), E6-AAa (Q14H/H78Y/83V) y E6-AAc (Q14H/I27RH78Y/L83V) and E6-reference of HPV-16 with MAG

Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.

PMID: 30930693 2019 Cancer cell international

Result: These caused the amino acid to change from threonine to serine (T22S), aspartic acid to asparagine (D25N), aspartic acid to glutamic acid (D25E), aspartic acid to glutamine (D25Q), isoleucine to arginine (I27R), asparagine to aspartic acid (N58D), asparagine to serine (N58S), aspartic acid to glutamic acid (D64E), leucine to valine (L83V), threonine to lysine (T86K), glutamic acid to aspartic acid (E113D), leucine to phenylalanine (L28F), asparagine to histidine (N29H) and asparagine to serine (N29S), respectively.

Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.

PMID: 25889023 2015 Virology journal

Introduction: Other polymorphisms including A131G, G132C, C143G, G145T, G176A, T178G and C335T generate the amino acid changes R10G/I, Q14H/D, D25E/N, I27R and H78Y, respectively.

Table: D25N

Discussion: According to the HPV variants found in this study, the amino acid substitutions circulating in Southern Mexico are: Q3E, R10G, Q14H, D25N, I27L, <

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