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 HPV mutation literature information.


  Polymorphism in the E6 gene of human papillomavirus type 16 in the cervical tissues of Korean women.
 PMID: 15670304       2005       International journal of gynecological cancer
Abstract: No significance difference was found between the frequencies of D25E variation in cancerous and non-cancerous lesions.
Abstract: The most frequently found variation was D25E (in NCD, n = 8, 80%; in CIN, n = 9, 52.9%; in ICC, n = 23, 85.2%).


  Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.
 PMID: 12918070       2003       International journal of cancer
Abstract: Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16).


  Co-mutation of HPV16 E6 and E7 genes in Thai squamous cervical carcinomas.
 PMID: 12820481       2003       Anticancer research
Abstract: A mutation from T to G at nucleotide 178, leading to a change from aspartate to glutamate (D25E), was the most common variation accounting for 70%.
Abstract: Interestingly, 90% of these E6 (D25E) variants coincided with a specific type of E7 mutation, N29S.
Abstract: This is the first finding of coordinated change between E6 (D25E) and E7 (N29S) in HPV, which might indicate a specific variant for the Thai population.


  Enhanced oncogenicity of human papillomavirus type 16 (HPV16) variants in Japanese population.
 PMID: 10880765       2000       Cancer letters
Abstract: The E6 D25E, a rare variant in Western countries, was most frequently observed in ICC (44%).



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