Abstract: The rank orders of incidence of E6 variations in amino acid were as follows: D25E (46.3%), L83V (9.9%) and H78Y (4.3%).
Result: Nucleotide variations of E6 included 4 silent mutations of G94A, G176A, C215T and T241G and 5 missense mutations of A131C, T178G/A, C335T, T350G and A442C, which led to amino acid variations of R10G, D25E, H78Y, L83V and
E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam.
Abstract: There was no significant relationship between abnormal cervical cytology and either HPV-16 E6/E7 lineages or specific amino acid mutations, such as E6 D25E, E6 L83V, and E7 N29S.
Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.
Abstract: Bayesian analysis identified several important amino acid positions that may be driving adaptive selection in the HPV 16 population, including R10G, D25E, L83V, and E113D in the E6 gene.
Table: D25E
Discussion: The other positively selected site of interest is amino position D25E.
Gene expression profiles are altered in human papillomavirus-16 E6 D25E-expressing cell lines.
Result: Our previous study showed that HPV-16 E6 D25E is
Result: The incidences of the variants in ICC from Japanese women were as follows: D25E in 44% of women, L83V in 28%, and other variants in 16%.
Result: The wild-type E6 and D25E variant genes were amplified from HPV-16-infected cervical swabs and inserted into a pLenti6.3/V5-TOPO lentiviral vector (Invitrogen, Carlsbad, CA, USA) followed by sequence analysis.
Result: There were 118 common transcripts revealed in both cell lines, 79 transcripts that were regulated by wild-type E6 and 14 transcripts that were unique in the E6 D25E-expressing cells.
Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China.
PMID: 21593270
2011
Journal of clinical microbiology
Abstract: The most prevalent amino acid variations were D25E in E6 and N29S in E7.
Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.
PMID: 21436703
2011
International journal of gynecological cancer
Abstract: Sequences of the E6 gene revealed 4 amino acid changes of variants D25E and L83V, with 48.3% (69/143) and 11.2% (16/143), respectively, and variants H78Y and E113D in this study.
Human papillomavirus type 16 E6 gene variations in Chinese population.
PMID: 19699050
2010
European journal of surgical oncology
Abstract: CONCLUSION: The D25 E variant is the most prevalent E6 genomic variant in Hubei, China.
Abstract: The rank orders of incidence of HPV 16 prototype and E6 variants were as follows: D25E (62%), the prototype (17%), E113D (9%), L83V (6%) in case subjects; the prototype (71%), D25E (23%), L83V/E113D (7%) in control subjects.
[Gene characterization of E6 and E7 gene of human papillomavirus of 15 cervical cancer in Beijing].
PMID: 20104743
2009
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: There were two nucleotide mutation at E6 position 178 (T-->G,D25E) and at E7 position 647 (A-->G, N29S) in 4 Asian type like viruses.
Gene expression profiles are altered in human papillomavirus-16 E6 D25E-expressing cell lines.
Abstract: Although this study has some limitations such as a small sample size and not enough clinical data, these finding suggests that the distinctive distribution of HPV 16 As-variant E6 D25E and E7 N29S might be associated with geographical dependence rather than disease progression.
Abstract: At the amino acid level, the isolates showed 14 variants including E6 Q14H, E6 D25E, E6 I27R, E6 H78Y, E6 L83V, and E7
Analysis of mutations in the E6/E7 oncogenes and L1 gene of human papillomavirus 16 cervical cancer isolates from China.
PMID: 16603519
2006
The Journal of general virology
Abstract: In addition to D25E and E113D, the following E6 variations were found in this study: R129K, E89Q, S138C, H78Y, L83V and F69L.
Abstract: Prevalences of HPV16 E6 D25E and E113D variants were 67.3 and 9 %, respectively.
HPV mutation literature information.
PMID: 
2013
BMC cancer
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