Introduction: For example, L83V (L90V) of HPV-16 E6 in Swedish and Italian populations as well as D25E (D32E) of HPV-16 E6 in Japanese populations have been proven to be associated with the progression of cervical cancer.
A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3.
Abstract: The HPV sequence analysis revealed that the HPV type 16 E6/E7 variants D25E, V83L, and N29S were inversely associated with histopathologic regression at V8.
Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.
Result: These caused the amino acid to change from threonine to serine (T22S), aspartic acid to asparagine (D25N), aspartic acid to glutamic acid (D25E), aspartic acid to glutamine (D25Q), isoleucine to arginine (I27R), asparagine to aspartic acid (N58D), asparagine to serine (N58S), aspartic acid to glutamic acid (D64E), leucine to valine ( Discussion: T178G (D25E) variations are mainly distributed in the Asian population (such as China, Japan and South Korea); the mutation can interact with Human Lymphocyte Antigen (HLA) gene polymorphisms and promote the development of cervical cancer.
Identification of the impact on T- and B- cell epitopes of human papillomavirus type-16 E6 and E7 variant in Southwest China.
Abstract: The mutations of D25E and L83V of E6 and N29S of E7 produce new epitopes, and the percentile values change with them.
Physical Status and Variant Analysis of Human Papillomavirus 16 in Women from Shanghai.
PMID: 25968097
2016
Gynecologic and obstetric investigation
Abstract: Amino acid changes of D25E and N29S were the most common variations across the genome.
Activities of E6 Protein of Human Papillomavirus 16 Asian Variant on miR-21 Up-regulation and Expression of Human Immune Response Genes.
PMID: 25987069
2015
Asian Pacific journal of cancer prevention
Abstract: CONCLUSIONS: E6D25E of the HPV16As variant differed from the E6 prototype in its activities on epigenetic modulation and immune surveillance and this might be a key factor for the important role of this variant in cervical cancer progression.
Abstract: HCK1T cells expressing E6D25E or E6Pro were established by transducing retrovirus-containing E6D25E or 16E6Pro.
Abstract: Interestingly, E6D25E showed a higher activity of miR-21 induction than did E6Pro in C33A cells expressing E6 protein.
Abstract: Interestingly, when treated with HeLa-CM, IRFs 1, 3 and 7 as well as c
Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Introduction: Other polymorphisms including A131G, G132C, C143G, G145T, G176A, T178G and C335T generate the amino acid changes R10G/I, Q14H/D, D25E/N, I27R and H78Y, respectively.
Prevalence of HPV and variation of HPV 16/HPV 18 E6/E7 genes in cervical cancer in women in South West China.
Abstract: There was no significant relationship between abnormal cervical cytology and either HPV-16 E6/E7 lineages or specific amino acid mutations, such as E6 D25E, E6 L83V, and E7 N29S.
HPV mutation literature information.
PMID: 
2022
Cancer cell international
Browser Board
Co-occurred Entities
Filtrator
ViMRT