Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.
Result: Five variants were found only among the non-malignant specimens namely, E7 (C790T:R77C), E2 (C3236G:H161D), E2/E4 (A3605G:284D), LCR (A7550G) and NCR-2 (T4222C), portraying significant p-values after multiple testing correction.
Discussion: Further, irrespective of the HPV16 lineages, our study also reflected the lack of genomic variations within the E7 gene among the CaCx cases, as opposed to a single variation (C790T) among the control
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
Result: A subset of the A2 sublineage appeared to be uniquely defined by the C335T (H85Y) and A442C (E120D) in E6 and A646C (N29H) in E7, and a subset of the A1 sublineage was uniquely defined by the C790T (R77C) in the E7 gene.
Table: C790T
Geographical dependence of sequence variation in the E7 gene of human papillomavirus type 16.
PMID: 1321216
1992
The Journal of general virology
Abstract: One tumour harbours HPV-16 DNA with a mutation (C to T) at nucleotide 790 changing the E7 amino acid sequence (arginine to cysteine) at position 76.
HPV mutation literature information.
PMID: 
2022
Translational oncology
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