literature

HPV mutation literature information.

Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells.

PMID: 33155930 2021 Anti-cancer agents in medicinal chemistry

Abstract: OBJECTIVE: This study aimed to determine whether the HPV58 E7 T20I (C632T) variant promotes the malignant behavior of cervical cancer cells and the underlying mechanism of the HR-HPV E7 oncoprotein involved in the development of cervical cancer.

The polymorphisms of LCR, E6, and E7 of HPV-58 isolates in Yunnan, Southwest China.

PMID: 29695285 2018 Virology journal

Discussion: The occurrence of C632T and G760A in the HPV-58 E7, which were identified in our study and resulted in the amino acid changes including T20I and G63S, respectively, has been implied to be linked to an increased risk for cervical cancer.

Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants.

PMID: 28794033 2017 Journal of virology

Result: For example, the A3 sublineage-specific nucleotide variations of E7 C632T (amino acid T20I); E1 C1965T; E2 A3685G; NCR2 A4192C; L2 G4570A, A4609G, and A4935C (N231T); L2/L1 A5579C (L2 M446L or L1 L5F); L1

Genetic Variability in E6 and E7 Oncogenes from Human Papillomavirus Type 58 in Mexican Women.

PMID: 29945151 2017 Intervirology

Abstract: For E7, 17 known mutations were found, the most frequent were C632T (T20I), 35.30%, G760A (G63S), 35.30%, and t744g 74.50%.

Genetic variability of HPV-58 E6 and E7 genes in Southwest China.

PMID: 24368255 2014 Infection, genetics and evolution

Abstract: 8 single nucleotide changes were identified among the HPV-58 E7 sequences with 2/8 synonymous mutations (T726C, T744G) and 6/8 non-synonymous mutations (G599A, C632T, G694A, G760A, G761A, T803C).

Abstract: The most common mutations of E7 genes are C632T, G694A, T744G, G760A (from Gly to Ser, in turn), G761A and T803C.

Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women.

PMID: 20870281 2010 Gynecologic oncology

Abstract: CONCLUSIONS: These findings suggest that C632T (T20I) and G760A (G63S) variants in HPV58 E7 are probably risk factors associated with the development of cervical cancer in Chinese women.

Abstract: For HPV58, the presence of C632T (T20I) and G760A (G63S) variants in E7 showed a positive trend of the association with the severity of neoplasia (P(trend)<0.05, chi2 test for trend).

Association of human papillomavirus type 58 variant with the risk of cervical cancer.

PMID: 12189229 2002 Journal of the National Cancer Institute

Abstract: Among HPV58-positive women, the occurrence of E7 632C-->T (T20I) and E7 760G-->A (G63S) variants (T20I/G63S) showed a positive trend of association with the severity of neoplasia (P(trend)<.001, chi(2) test for trend).

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