Result: A subset of the A2 sublineage appeared to be uniquely defined by the C335T (H85Y) and A442C (E120D) in E6 and A646C (N29H) in E7, and a subset of the A1 sublineage was uniquely defined by the C790T (R77C) in the E7 gene.
Result: However, both C335T (H85Y) and A646C (N29H) non-synonymous substitutions appeared in 7% (21/298) of HPV16 isolates at the same time in this TZHPV study.
Result: Notably, C335T (
Phylogenetic analysis of Human papillomavirus 16 variants isolated from Indian Breast cancer patients showed difference in genetic diversity with that of cervical cancer isolates.
Abstract: Whereas, 145 G>T (Q14H) and 335 C>T (H78Y) variants of E6 showed association with either early invasiveness of BC and/or poor outcome of the patients.
Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Introduction: Other polymorphisms including A131G, G132C, C143G, G145T, G176A, T178G and C335T generate the amino acid changes R10G/I, Q14H/D, D25E/N, I27R and H78Y, respectively.
Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates.
Result: All African lines showed a common pattern of five characteristic mutations in E6, namely,
Result: The most frequently observed variations were C143G (Q14D), G145T (Q14D), T286A, A289G and C335T (H78Y), which was found in all samples.
Discussion: At the E6 genomic region, five characteristic mutations, C143G, G145T, T286A, A289G, and C335T defining the African lineage were found in our study as well as it's was previously described.
Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
Abstract: At the amino acid level, the most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C), Q14D (C143G/G145T) and R10I (G132T), and were observed respectively in 65%, 41.8%, 38.8%, 30.1% and 23.3% of total samples.Moreover, HPV16 European variants were mostly identified in younger women at early clinical diagnosis stages.
Discussion: The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T),
Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
Result: Nucleotide variations of E6 included 4 silent mutations of G94A, G176A, C215T and T241G and 5 missense mutations of A131C, T178G/A, C335T, T350G and A442C, which led to amino acid variations of R10G, D25E, H78Y, L83V and E113D, respectively.
[Gene characterization of E6 and E7 gene of human papillomavirus of 15 cervical cancer in Beijing].
PMID: 20104743
2009
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: There were one nucleotide mutation at E6 position 335 (C-->T, H78Y) in 1 of 4 Europe prototype like virus.
Human papillomavirus typing of invasive cervical cancers in Italy.
Result: Sequence analysis of the E6 gene in 25 HPV 16 positive ICC cases showed the presence of the T350G mutation in the great majority (18/25, 72%), in 4 cases also accompanied by other mutations; among the mutations identified, A257G, C335T, T350G, A442C lead to amino acid changes (I52V, H78Y, L83V, E113D, respectively), while C256T, T286A, A289G are silent not leading to amino acid changes.
Result: The E6 pattern corresponded to the prototype in 7 c
HPV mutation literature information.
PMID: 
2021
BMC cancer
Browser Board
Co-occurred Entities
Filtrator
ViMRT