Result: Moreover, our data showed that the oncogenicity of HPV16 E6 T178G (D32E) and E7 A647G (N29S) variation was associated with an increased risk of CIN2+ (OR = 2.24 ~ 2.45)
Result: The three most prevalent nucleotide substitutions were T178G (D32E) (191/298, 64.1%) in the E6 gene and A647G (N29S) (195/298, 65.4%) and T846C (192/298, 64.4%) in the E7 gene, which are specific to the A4 (Asian) sublineage.
Table: A647G
Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.
Result: Notably, 18 cases of the A647G mutation were combined with the T178G mutation, and we considered that the A647G of E7 and T178G of E6 were co-variations.
D
Discussion: However, it has been reported that joint mutation of E6 T350G and E7 A647G may be Chinese specific.
Discussion: In addition, most of the mutations in A647G occur in the As sub-lineage.
Discussion: The results of this study show that the common polymorphism site of the E7 gene is A647G, which is similar to the results of Yang et al.
Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates.
Result: However, the common non-synonymous mutation A to G transition at nt 647 and causing amino acid change N29S, was found in 3 (23.0%) out of 13 sequences.
Discussion: But it was also proved that the variant A647G only binds with similar affinity to that of the prototype.
Intratypic variants of human papillomavirus type 16 and risk of cervical neoplasia in Taiwan.
Abstract: Similar significant associations with cervical intraepithelial neoplasia grade 3 or worse were also observed for distinct nucleotide substitutions, including T178A/G, A647G, A7730C/G, T7781C, G7842A, and C24T/G.
Research on sequence variations analysis of HPV-16 type in Southwestern China.
PMID: 24601042
2013
European journal of gynaecological oncology
Abstract: RESULTS: Compared with the European-Germanyl31 (EG131), 20 mutations were detected, of which eight mutations were detected from all the four biopsies: 131(G-A)(Gly-Arg), 178 (T-G)(Asp-Glu),350 (G-T)(Val-Leu), 647 (A-G)(Asn-Asp),846 (T-C) (synonymous mutation), L1 966th (C-T)(synonymous mutation),L1 1302 (C-T)(synonymous mutation) and L1 1434th (A-G) (synonymous mutation).
Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China.
PMID: 21593270
2011
Journal of clinical microbiology
Abstract: The most frequently observed variation sites were T178G (32.69%) in E6; A647G (34.62%), G666A (38.46%), and T846C (32.69%) in E7; C6826T (36.17%) and G7060A (61.70%) in L1; and G7521A (98.08%) in the LCR.
[Human papillomavirus type 16 variant analysis of upstream regulatory region and E6, E7 oncogene from cervical cancer patients in Beijing].
Abstract: A total of 8 hot mutation spot was identi-fied, which were URR G7521A (100%), C7435G (96.77%), C24T (45.16%), A7729C (45.16%), G7839A (45.16%), E6 T178G (41.94%), E7 A647G (45.16%), and T846C (45.16%).
Abstract: Our results suggested that the mutations of G7521A, A7729C, G7839A, T178G, T350G, A647G, and G658A were likely to be a
[Gene characterization of E6 and E7 gene of human papillomavirus of 15 cervical cancer in Beijing].
PMID: 20104743
2009
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: There were two nucleotide mutation at E6 position 178 (T-->G,D25E) and at E7 position 647 (A-->G, N29S) in 4 Asian type like viruses.
Sequence variation and the transcriptional activity of the upstream regulatory region in human papillomavirus 16 E7 variants in cervical cancer of Korean women.
Abstract: Using PCR-directed sequencing, the presence of sequence variations in URRs were analyzed and the sites of sequence variation were matched with the known transcriptional factor binding site (TFBS) in 26 HPV 16 E7 variants, 21 cases with A647G (KE7-1, high oncogenic potential) and 5 cases with T732C (KE7-2, low oncogenic potential).
Major sequence variants in E7 gene of human papillomavirus type 16 from cervical cancerous and noncancerous lesions of Korean women.
HPV mutation literature information.
PMID: 
2021
BMC cancer
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