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 HPV mutation literature information.


  Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
 PMID: 34217247       2021       BMC cancer
Result: A subset of the A2 sublineage appeared to be uniquely defined by the C335T (H85Y) and A442C (E120D) in E6 and A646C (N29H) in E7, and a subset of the A1 sublineage was uniquely defined by the C790T (R77C) in the E7 gene.
Table: A442C


  Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.
 PMID: 30930693       2019       Cancer cell international
Result: Nineteen single nucleotide changes were identified among the sequencing results for E6 and E7, including 14 missense mutations and five synonymous mutations: 11/14 missense mutations were distributed in the E6 gene (C168G, G176A, T178G, T178A, T183G, A275G, A276G, T295G, T350G, C360A and A442C) and 3/14 missense mutations (A645C, A646C, A647G) were located in the E7


  Variant sublineages of human papillomavirus type 16 predispose women to persistent infection characterized by a sequence analysis of the E6, L1, and LCR regions.
 PMID: 31933750       2019       International journal of clinical and experimental pathology
Abstract: In addition, the A4 sublineage T178G (P<0.001) and the A1/A2 sublineages T350G and A442C (P<0.001) were associated with persistent HPV16 infection.


  Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization.
 PMID: 27038009       2016       Journal of medical virology
Abstract: (ii) The European variant E6 T350G/A442C may be associated with higher rates of recurring and persistent HPV16 infection after the LEEP.
Abstract: The patients with European variants T350G or A442C had a significantly higher incidence of persistent and recurring HPV16 infection.


  HPV16 E6 mutations and p53 codon72 polymorphism among women with cervical intraepithelial neoplasia 2 and 3 in China.
 PMID: 29787003       2016       European journal of gynaecological oncology
Abstract: RESULTS: Among the 85 amplified HPV sequences, point mutations such as T178G, T350G, G132A, A442C, T310G, G94T, C551A, etc.


  Variants of human papillomavirus type 16 predispose toward persistent infection.
 PMID: 26339417       2015       International journal of clinical and experimental pathology
Abstract: It was found that the variants T178G, T350G and A442C in the E6 gene, as well as C3158A and G3248A variants in the E2 gene were associated with persistent HPV16 infection.


  Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
 PMID: 23953248       2013       BMC infectious diseases
Result: The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C) and Q14D (C143G/G145T) and were observed respectively in 65%, 41.8%, 38.8% and 30.1% of total samples.
Discussion: The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C), Q14D (C143G/G145T) and R10I (


  Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
 PMID: 24099556       2013       BMC cancer
Result: Nucleotide variations of E6 included 4 silent mutations of G94A, G176A, C215T and T241G and 5 missense mutations of A131C, T178G/A, C335T, T350G and A442C, which led to amino acid variations of R10G, D25E, H78Y, L83V and E113D, respectively.


  Human papillomavirus typing of invasive cervical cancers in Italy.
 PMID: 17192187       2006       Infectious agents and cancer
Result: Sequence analysis of the E6 gene in 25 HPV 16 positive ICC cases showed the presence of the T350G mutation in the great majority (18/25, 72%), in 4 cases also accompanied by other mutations; among the mutations identified, A257G, C335T,
Result: The E6 pattern corresponded to the prototype in 7 cases, while the T350G mutation was present in 18; as single mutation in 14, with another mutation in 3 (T256C, A257G, A442C, respectively), and with three additional mutations in 1 (T286A, A289G, C335T).


  Analysis of relative binding affinity of E7-pRB of human papillomavirus 16 clinical variants using the yeast two-hybrid system.
 PMID: 10861636       2000       Journal of medical virology
Abstract: Particularly, a prevalent (64.7%) E6 polymorphic site A442C with an E113D amino acid substitution seems specific to Taiwanese patients.



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