Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai.
Result: C307T and A388C were identified in 36% variants (4/11).
Result: C321T and A388C resulted in the amino acid changes including S71F and K93 N, respectively.
Result: The A to C substitution at the nucleotide site 388 resulted in the change of residue 93 (K to N), where the MHC class-I binding peptide TLKKCLNEI (E6 91-99) was located.
Discussion: And the most common non-synonymous substitutions in the HPV-58 E6 and E7 were A388C (K35 N) and T803C (V77A), respectively.
E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.
Discussion: The most common mutations observed in HPV-33 E6 were A231C (K35N, 42/216, a positive mutation) and A387C (K93N, 42/216, a positive mutation); in HPV-33 E7 were G658C (S29T, 36/216, a positive mutation) and C706A (A45E, 27/216); in HPV-58 E6 were C307T (237/405) and A388C (K93N 111/405); while the most common non-synonymous mutations in HPV-58 E7 were T744G (319/405) and G761A (
Genetic variability of HPV-58 E6 and E7 genes in Southwest China.
PMID: 24368255
2014
Infection, genetics and evolution
Abstract: 4 single nucleotide changes were identified among the E6 sequences with 3/4 synonymous mutations (C187T, A260C, C307T) and 1/4 non-synonymous mutations (A388C, from Lys to Asn, in alpha helix).
Abstract: The most common mutations of E6 genes are the C307T and A388C.
HPV mutation literature information.
PMID: 
2019
Infectious agents and cancer
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