literature

HPV mutation literature information.

Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.

PMID: 35246180 2022 Virology journal

Result: The most prevalent non-synonymous mutations in E6 genes was A379G (14/15) and cause the amino acid to change from Lysine to arginine (K93R).

The genetic variability, phylogeny and functional significance of E6, E7 and LCR in human papillomavirus type 52 isolates in Sichuan, China.

PMID: 33941222 2021 Virology journal

Result: A378C and A379G together led to the amino acid substitution of K93R.

Result: G108C and A379G, leading to the amino acids substitution of E3Q and K93R, respectively.

Result: G350T and A379G were the most variable sites and were observed in 100% and 97.56% (40/41) of the samples, respectively.

Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea.

PMID: 27977741 2016 PloS one

Abstract: We also found that a lineage B-specific mutation K93R (A379G) was associated with an increased risk of cervical neoplasia.

Result: Of the 91 samples, K93R (A379G), the most frequently detected nonsynonymous mutation (85.71%) in E6, was only found in lineage B.

Table: A379G

Genomic polymorphism of human papillomavirus type 52 in women from Northeast China.

PMID: 23203106 2012 International journal of molecular sciences

Result: Compared to the reference sequence, all the obtained sequences harbored the nucleotide variation of G350A and 65 had the nonsynonymous mutation of A379G (K93R) in the E6 gene (Table 2).

Result: The A379G (K93R) mutation was located in the strand H1 and the third predicted zinc finger of E6 protein.

Discussion: Among the four mutations, only A379G (K93R) was nonsynonymous.

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