HPV mutation literature information.


  Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.
 PMID: 30930693       2019       Cancer cell international
Discussion: In addition, Eur viruses have been divided into a few small branches, such as E-T350 (Ep), E-G350 (T350G), E-G131 (A131G) and E-C109 (T109C).


  Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
 PMID: 25889023       2015       Virology journal
Introduction: Other polymorphisms including A131G, G132C, C143G, G145T, G176A, T178G and C335T generate the amino acid changes R10G/I, Q14H/D, D25E/N, I27R and H78Y, respectively.


  Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
 PMID: 23953248       2013       BMC infectious diseases
Result: The other non-synonymous variants were R10I (G132T), R10G (A131G), D64E (T295G), Q14H (G145T) and A61G (C285G) and were seen in 23.3%, 6.8%, 6.8%, 1.9% and 1% of cases respectively.
Table: A131G


  Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
 PMID: 24099556       2013       BMC cancer
Result: Two nonsynonymous variations of A131G (R10G) and T350G (L83V) were observed in HPV16 E6 gene.


  Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden.
 PMID: 22558401       2012       PloS one
Result: The most remarkable difference between TSCC and CC was found with regard to the frequencies of the E-A131G variant causing a change from arginine to glycine in a.a.


  Identification of HPV variants.
 PMID: 16350393       2005       Methods in molecular medicine
Abstract: In particular, we describe methods for the identification of variation within the HPV-16 E5 open reading frame and for the detection of the nt 131 A-->G mutation of the E6 ORF, using restriction fragment length polymorphism assays.


  Human papillomavirus type 16 E6 and E7 genotypes in head-and-neck carcinomas.
 PMID: 15006625       2004       Oral oncology
Abstract: Sequence analysis of the E6-E7 segments revealed three different HPV16 E6-E7 genotypes: the HPV16 prototype (6 of 21 cases), the E6 variant T350G (8 of 21 cases), and the E6-E7 variant A131G/C712A (7 of 21 cases).
Abstract: The E6 variants T350G and A131G have been associated with increased oncogenic potential in cervical cancer patients depending on host genetic factors.



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