Result: Specifically, we introduced C7732G in LCR-PT, either alone or in combination with 79del, as found in the A2-variants LCR6 and LCR14.

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Discussion: Thus, the comparable activities of the prototype and variants LCRs in HeLa cells can be explained by the fact that some variations like C7732G and 79del only have a minor effect and by the observation that the more active variations antagonize each other as seen for 79del/ Discussion: Thus, while the stimulation of the EP by the 79-bp duplication could contribute to the oncogenicity of A1 variants, the lower transcriptional activity of A2- and B-variants caused by 79del may increase their persistence.

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