Result: Next, we examined the localization of Gag and Env in VS target cells after HIV-1 cell-cell transfer conducted with the WT or Y712A mutant.
Result: Overall, this led to a 4-fold increase in the Env-to-Gag ratio detected in target cells co-cultured with HIV Y712A-infected donor cells, as compared to those co-cultured with WT HIV-infected cells (Figure 5G).
Result: When examining the signal intensity of Env and Gag within co-localized puncta, we observed a 3-fold increase in the Env intensity in Y712A Env vs.
The membrane-proximal tyrosine-based sorting signal of human immunodeficiency virus type 1 gp41 is required for optimal viral infectivity.
Abstract: In spreading infections, including those using primary lymphocytes, the growth of the Y712A mutant was as impaired as Nef-negative virus, and the EnvY712A/Delta-Nef combination mutant was almost completely defective.
HIV mutation literature information.
PMID: 
2021
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