Mutational analysis of Tyr-318 within the non-nucleoside reverse transcriptase inhibitor binding pocket of human immunodeficiency virus type I reverse transcriptase.
PMID: 9852086
1998
The Journal of biological chemistry
Abstract: Recombinant viruses harboring the Y318F or Y318W mutation in the RT showed a similar resistance/sensitivity pattern to NNRTIs as their corresponding 318 mutant recombinant RTs.
Abstract: Using site-directed mutagenesis, six mutant Abstract: We found that only the Y318W and Y318F mutant RTs retained substantial RT activity, whereas the catalytic activities of the Y318K, Y318C, Y318H, and Y318L RT mutants were less than 5% of the wild-type activity.
HIV mutation literature information.
PMID: 
1998
The Journal of biological chemistry
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