literature

HIV mutation literature information.

Could Long-Acting Cabotegravir-Rilpivirine Be the Future for All People Living with HIV? Response Based on Genotype Resistance Test from a Multicenter Italian Cohort.

PMID: 35207677 2022 Journal of personalized medicine

Method: Furthermore, we excluded people with the following mutations for NNRTI: L100I, K101E/H/NP/Q, E138A/G/K/Q/R, V179L, Y181C/F/G/I/S/V, Y188L, G190A/C/E/Q/S/T/V, H221Y, F227C/L, and M230L.

Prevalence of doravirine cross-resistance in HIV-infected adults who failed first-line ART in China, 2014-18.

PMID: 35134966 2022 The Journal of antimicrobial chemotherapy

Abstract: High-level resistance was mainly due to Y188L (3.2%) and M230L (2.7%).

Evaluation of doravirine-based regimen population target in a large Italian clinical center.

PMID: 35485330 2021 Antiviral therapy

Abstract: The most common DOR-related RAM were V106A, Y181V, and Y188L.

HIV Pretreatment Drug Resistance Trends in Mexico City, 2017-2020.

PMID: 34959542 2021 Pathogens (Basel, Switzerland)

Result: The relatively high resistance to doravirine is noteworthy, and was mainly associated with mutations Y188L (4.5%, in most cases combined with V106I), L100IV (4.5%), K103EP (3.8%), P225H (3.0%).

Prevalence and factors associated with HIV-1 drug resistance mutations in treatment-experienced patients in Nairobi, Kenya: A cross-sectional study.

PMID: 34622871 2021 Medicine

Result: K103N/S 56 (21.0%), G190S/A 39 (14.6%), Y181C/I 29 (10.9%), V108I 13 (4.9%), P225H 12 (4.5%), Y188L 7 (2.6%), M230L 7 (2.6%), L100I 5 (1.9%), V106 M 5 (1.9%), and K101P 2 (0.7%) were the mutations conferring resistance to NNRTIs.

Correlation of HIV-1 drug resistant mutations and virologic failure.

PMID: 34584606 2021 The Pan African medical journal

Table: Y188L

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.

PMID: 34377002 2021 Infection and drug resistance

Table: Y188C/H/L

HIV Drug Resistance Mutations Detection by Next-Generation Sequencing during Antiretroviral Therapy Interruption in China.

PMID: 33668946 2021 Pathogens (Basel, Switzerland)

Result: Within a year, some minority DRMs at frequencies 1%-10% remained unchanged, including: PI-related D30N, M46LI, I54VT and N88D, NRTI-related K65R and NNRTI-related Y188CHL.

Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction.

PMID: 33477685 2021 Viruses

Discussion: The highest levels of doravirine resistance (fold-change >100) have been associated with amino acid substitutions V106A/G190A/F227L, E138K/Y181C/M230L and Y188L (alone or in combination with K103N or V106I).

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy.

PMID: 32111013 2020 Molecules (Basel, Switzerland)

Result: However, in the Y188L RT (Figure 4H), the compound 10p lost the hydrogen bond between 4'-CN and Y188 and decreased pi-pi stacking interactions.

Result: That might explain the higher antiviral activity against the E138K mutant than against the Y188L mutant.

Result: These compounds were also tested in the MT-4 cells for their activities against the single mutant (L100I, E138K, Y181C, K103N, Y188L) and double RT mutant (K103N + Y181C, F227L +

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