literature

HIV mutation literature information.

Minority variants associated with transmitted and acquired HIV-1 nonnucleoside reverse transcriptase inhibitor resistance: implications for the use of second-generation nonnucleoside reverse transcriptase inhibitors.

PMID: 19734799 2009 Journal of acquired immune deficiency syndromes (1999)

Method: L100I, K101E/P, K103N/S, V106A/M, Y181C/I/V, V179F, Y188C/H/L, G190A/S/E/Q and M230L were defined as major NNRTI resistance mutations.

Result: Ten of the 12 samples had a total of 14 non-etravirine resistance mutations including V108I (n=6), P225H (n=3), K101N (n=1), Y188C (n=1).

Nevirapine resistance in women and infants after first versus repeated use of single-dose nevirapine for prevention of HIV-1 vertical transmission.

PMID: 18582198 2008 The Journal of infectious diseases

Table: Y188C

Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-Dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission.

PMID: 18684096 2008 The Journal of infectious diseases

Table: Y188C

Variability in the plasma concentration of efavirenz and nevirapine is associated with genotypic resistance after treatment interruption.

PMID: 19043929 2008 Antiviral therapy

Abstract: Moreover, minority HIV-1 variants containing different resistance patterns (V1061/A, K103R/E or Y188C/D/H) were detected regardless of NNRTI concentrations.

Selection and persistence of viral resistance in HIV-infected children after exposure to single-dose nevirapine.

PMID: 17117145 2007 Journal of acquired immune deficiency syndromes (1999)

Abstract: RESULTS: Of 53 HIV-infected infants, 24 (45.3%) had detectable resistance at their first visit, when the most frequent mutations were Y181C (75%), K103N (25%), and Y188C (12%).

Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.

PMID: 17441703 2007 Journal of medicinal chemistry

Abstract: In a mutated NNRTI pocket, GW420867X either remains in a similar position compared to wild-type (RT(Leu100Ile) and RT(Tyr188Cys)) or rearranges within the pocket (RT(Lys101Glu)).

HIV-1 subtype B protease and reverse transcriptase amino acid covariation.

PMID: 17500586 2007 PLoS computational biology

Method: NNRTI-selected mutations included A98G, L100I, K101E/P/N/H, K103N/S, V106A/M, V108I, V179D/E, Y181C/I/V, Y188L/C/H, G190A/S/E/Q, P225H, F227L, M230L, P236L, and K238T.

Evidence of differential selection of HIV-1 variants carrying drug-resistant mutations in seroconverters.

PMID: 16759049 2006 Antiviral therapy

Abstract: Among the mutations not detected in viruses from SCs, the RT E44D, V1081, Q151M and Y188C/H/L, and the protease D30N, G48V and V82A/F/S/T substitutions appeared to be negatively selected.

Emergence of antiretroviral therapy resistance-associated primary mutations among drug-naive HIV-1-infected individuals in rural western Cameroon.

PMID: 16885781 2006 Journal of acquired immune deficiency syndromes (1999)

Abstract: Reverse transcriptase inhibitor-associated primary resistance mutations were found in 5 (9.8%) samples: Y188C in 2 cases, and L100I, M184V, and V75I in 1 case each, although all of these mutations were found as minor populations.

Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.

PMID: 16189079 2005 Antimicrobial agents and chemotherapy

Abstract: In HeLa CD4 MAGI cell culture virus replication assays, GW678248 has an IC(50) of < or =21 nM against HIV-1 isogenic strains with single or double mutations known to be associated with NNRTI resistance, including L100I, K101E, K103N, V106A/I/M, V108I, E138K, Y181C, Y188C, Y188L, G190A/E, P225H, and P236L and various combinations.

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