Genetic Analyses of HIV-1 Strains Transmitted from Mother to Child in Northern Vietnam.
PMID: 25826000
2015
AIDS research and human retroviruses
Abstract: Y181C, a nevirapine resistance mutation, appeared in two (25%) children 1 and 3 months after birth, respectively.
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
Abstract: Four NNRTI SDRMs:K101E, K103N, Y181C, and G190A:accounted for >80% of NNRTI-associated TDR in all regions and subtypes.
Result: Etravirine and rilpivirine resistance was usually caused by Y181C, a mutation selected primarily by nevirapine.
Result: Of the 19 NNRTI SDRMs, Y181C accounted for a higher proportion of Result: Of the 19 NNRTI SDRMs, four mutations:K101E, K103N, Y181C, and G190A:occurred in >=0.1% of the 50,870 viruses from all regions.
Distinct drug resistance profile of HIV-1 subtype A strain circulating in Georgia.
Abstract: Frequent co-occurrence of G190S with Y181C and K101E may limit the use of novel generation NNRTIs in subtype A infected patients with previous exposure to this drug class.
Abstract: In 69 samples G190S co-occurred with either K101E or Y181C or with both: 39 genotypes G190S/K101E; 10 genotypes G190S/Y181CI and 20 genotypes G190S/K101E/Y181CI.
Abstract: Other significant NNRTI mutations included K101E
High level of HIV-1 drug resistance among patients with HIV-1 and HIV-1/2 dual infections in Guinea-Bissau.
Genetic Diversity and Drug Resistance Among Antiretroviral Treatment-Failed Individuals from 2010 to 2012 in Honghe, China.
PMID: 25919896
2015
AIDS research and human retroviruses
Abstract: Mutations such as M184V, A62V, T69Ins, K103N, Y181C, and G190A were common among the ART-failed individuals.
Single Genome Analysis for the Detection of Linked Multiclass Drug Resistance Mutations in HIV-1-Infected Children After Failure of Protease Inhibitor-Based First-Line Therapy.
PMID: 25923117
2015
Journal of acquired immune deficiency syndromes (1999)
5Result: In ""J,"" Y181C was detected at a frequency of 5% at week 40 of ART with SGS but was not detected by bulk sequence analysis at this time point."
5Result: More than 1 RT DRM linked on the same genome
8Discussion: The baseline PI DRM I50V, TAM revertant K215I, and the TAM K219N of the double mutant Y181C + K219N that were detected in ""D, E, and J"" may have also been vertically transmitted."
Result: Bulk sequence analyses detected baseline NVP-selected resistance in 5 of 10 children: K103N, V106M, and Y188C in 1 child each and Y181C in 2 children.
A post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum single-dose nevirapine to prevent mother-to- child HIV-1 transmission.
Result: Fifteen (34%) patients had mutations (viz K103N, Y181C, Y188C, Y188HY, and G190AG) associated with high level resistance to NNRTI, in particular NVP, whilst 1 (2%) patient had K101E associated with intermediate resistance to NNRTIs.
Discussion: A pooled analysis of sequences submitted to genbank from TDR surveys conducted in SA over 10 years also found K103N followed by Y181C to be the most common TDR mutation in SA [Manasa, 2012].
Change in the Prevalence of HIV-1 and the Rate of Transmitted Drug-Resistant HIV-1 in Haiphong, Northern Vietnam.
PMID: 25970090
2015
AIDS research and human retroviruses
Abstract: Nonnucleoside RT inhibitor-resistant mutations, Y181C/I, were detected in three subjects; one had the nucleoside RT inhibitor-resistant mutations L74V and M184V and one had E138K.
Different Effects of Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Cytotoxic T Lymphocyte Recognition between HIV-1 Subtype B and Subtype A/E Infections.
Abstract: RT181 mutations affected CTL recognition in both subtype A/E and B infections, while the RT Y181C mutation has been accumulating in treatment-naive Vietnamese.
Abstract: The Y181C mutation may influence HIV-1 control by the CTLs in Vietnam, since this mutation has been accumulating in treatment-naive Vietnamese.
Abstract: The Y181C mutation was found to be accumulating in treatment-naive Vietnamese infected with the subtype A/E virus.
Abstract: The results suggest that the Y181C mutation may influence HIV-1 control by CTLs in Vietnam.
Abstract: We investigated the effect of nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI
Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
Result: It is noteworthy that several major mutations associated to high level resistance to NRTIs (K65R, L74V, Y115F, M184V and T215Y), to NNRTIs (l100I, K101E, K103N/S, V106M, Y181C, Y188L and G190A) and to PIs (D30N, M46I/L, I54V/T, L76V, V82A,
HIV mutation literature information.
PMID: 
2015
AIDS research and human retroviruses
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