literature

HIV mutation literature information.

Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals.

PMID: 33173092 2020 Scientific reports

Result: These results indicate that the HLA-B*51:01-adapted Y120F/Q125H mutations selectively impaired Nef's ability to counteract SERINC3/5 but that CD4, CCR5, CXCR4 and HLA downregulation functions and CD74 upregulation function remained unaffected.

Discussion: The highly conserved D123 residue (> 99% prevalence in subtype A, B, C and D) is encompassed by the immune-escape mutation sites of Y120F and Discussion: We have demonstrated here that a number of naturally-occurring Nef variants (Y120F and Q125H) associated with a certain HLA class I allele (HLA-B*51:01) inversely correlated with the plasma viral load in treatment-naive HIV-infected patients harboring this HLA allele.

[Analysis of HIV-1 (Human immunodeficiency virus-1, Lentivirus, Orthoretrovirinae, Retroviridae) Nef protein polymorphism of variants circulating in the former USSR countries.]

PMID: 32168442 2019 Voprosy virusologii

Abstract: RESULTS AND DISCUSSION: The existence of noticeable differences in the prevalence of Nef natural polymorphisms (A32P, E38D, I43V, A54D, Q104K, H116N, Y120F, Y143F, V168M, H192T, V194R, R35Q, D108E, Y135F, E155K, E182M, R184K and F191L), some of which are characteristic mutations for variant A6, was shown.

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