Discussion: Interestingly, the Y115F mutation is reported to be associated with the HIV-1 drug (ABC and TDF) resistance and is the only amino acid substitution that does not reduce the HIV-1 RT enzyme activity.
Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana.
Result: The major DRAMs to NRTIs seen in this group were M184 V, Y115F, K70R, K219E and M41 LM while the minor DRAMs to NRTIs seen were T215S, T215I and D67G.
Table: Y115F
Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.
Discussion: TDF was used in the second-line program; the mutations associated with resistance to TDF were K65R, TAM (M41 L, K70R, L210 W, T215F), D67N, K70E, and Y115F.
Discussion: The K70E and Y115F mutations cause low-level resistance to TDF as well.
Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis.
HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa.
PMID: 28129253
2017
Journal of acquired immune deficiency syndromes (1999)
Result: After adjustment, participants on zidovudine at failure were more likely to have T215F, T215Y, M41L, K70R, D67N, L210W, type-1 thymidine analog, type-2 thymidine analog, and any thymidine analogue mutations (TAMs); those on tenofovir to have K65R, K70E, Y115F, and M184I; those on efavirenz to have K103N, P225H, Y188L, and L100I; and those on nevirapine to have Y181C and G190A.
Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.
Abstract: Of the 33 NRTI-associated TRAMs, 12 - A62V, K65R/N, S68G/N/D, K70E/Q/T, L74I, V75L, and Y115F - were more common among individuals receiving a first-line TDF-containing compared to a first-line thymidine analog-containing regimen.
Result: Of the 83 TRAMs, 16 (21%; 16/83) were established NRTI-associated resistance mutations including A62V, K65R/N, T69deletion, K70E/Q/T/N, L74V/I, V75M/I/L, Y115F, and
High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa.
Result: More than half of these mutations (K65R, D67N, K70R, L74V, V75I/S, Y115F, K219Q/E, K101E/P/H, K103N, V106AM, Y181C and Y188L/H) were significantly more prevalent (p < 0.05) in the rural settings of Limpopo than in urban Pretoria (Table 2).
Table: Y115F
Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Discussion: But on the other side, a stable rate of selection was also observed for some NRTI mutations (such as Y115F, L210W) and several NNRTI mutations (such as L100I, K101E, P225H and M230L).
Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.
Method: Other major NRTIs resistance mutations detected included the multidrug resistance mutation T69D, the thymidine analogue mutation (TAM) T215F, and the non-TAMs K65R and Y115F (Table 3).
Method: These transmitted DRMs included major resistance mutations to NRTIs such as M184V, T69D, T215F, K65R, and Y115F; and major resistance mutations to non-Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NNRTIs) such as Y181C, Table: Y115F
HIV mutation literature information.
PMID: 
2018
Cell chemical biology
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