Comparison of genotypic and virtual phenotypic drug resistance interpretations with laboratory-based phenotypes among CRF01_AE and subtype B HIV-infected individuals.
Result: RT RAMs were A62V, D67N, V75I, F77L, K101H, Y115F, F116Y, Q151M, Y181C, G190A and K219E.
Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY(R) System.
Abstract: Among the 40 ART-naive patients, two mutations associated with nucleoside reverse transcriptase inhibitor (NRTI) resistance (two with Y115F and T215I) and three associated with non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance (two with G190S and Y181C, four with V179T) were found.
Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template.
Abstract: Finally, the RT mutant Y115F displayed lower discrimination against rNTPs due to its increase in binding affinity for non-canonical rNTPs.
Introduction: Y115F) decreases RT's ability to discriminate rNTPs from dNTPs, which warrants further pre-steady state kinetic investigation.
Introduction: An amino acid substitution at this position (Y115F) for HIV-1 RT has also been associated with low-level resistance to several nucleoside reverse transcriptase inhibitors (NRTI).
Method: For Y115F RT, a 24-mer DNA primer (5'-TCAGGTCCCTGTTCGGGCGCCACT) was annealed to a 36-mer DNA template (5'-TCTCTAGCAGTGGCGCCCGAACAGGG
Prevention of mother-to-child HIV-1 transmission in Burkina Faso: evaluation of vertical transmission by PCR, molecular characterization of subtypes and determination of antiretroviral drugs resistance.
Abstract: Y115F was absent in the d4T group, and detected in 13.8% (n = 11) of TDF-exposed patients, p = 0.0007.
Abstract: Virus from 9 of the 11 patients (82.0%) who developed the Y115F mutation also developed K65R.
Result: Nine of the 11 patients (82.0%) who developed the Y115F also developed the K65R mutation.
Discussion: In vitro experiments with TDF-3TC exposure showed that Y115F is commonly selected after the development of K65R, which is reflected in our data as K65R was present in nine out of 11 of the patients with Y115F.
Discussion: The sole presence of K65R causes intermediate resistance to TDF whereas the com
Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.
Result: A wide range of mutations conferring multi-NRTI resistance were also observed, including M41L (n = 7, 10%), A62V (n = 15, 22%), D67N (n = 10, 15%), K70R (n = 10, 15%), V75I (n = 2, 3%), F77L (n = 1, 1%), Y115F (n = 6, 9%), F116Y (n = 1, 1%), Q151M (n = 1, 1%), L210W (n = 3, 4%), T215Y/F (n = 7, 10%) and (n = 5, 7%), and K219Q/E (n = 4, 6%) and (n = 7, 10%).
Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
Result: It is noteworthy that several major mutations associated to high level resistance to NRTIs (K65R, L74V, Y115F, M184V and T215Y), to NNRTIs (l100I, K101E, K103N/S, V106M, Y181C, Y188L and G190A) and to PIs (D30N, M46I/L, I54V/T, L76V, V82A, I84V, N88D
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
HIV mutation literature information.
PMID: 
2016
Journal of medical virology
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