Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors.
PMID: 30648556
2019
Biochemical and biophysical research communications
Abstract: The most active RT mutant, HIV-1 RT7MC, carrying Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L was successfully crystallized, and its three-dimensional structure was determined in complex with DNA:dGTP/entecavir-triphosphate (ETV-TP), a potent anti-HBV guanosine analogue RT inhibitor, at a resolution of 2.43 A and 2.60 A, respectively.
Drug resistance mutations and viral load in human immunodeficiency virus type 2 and dual HIV-1/HIV-2 infected patients in Ghana.
Abstract: HIV-2 drug resistance mutations (M184V, K65R, Y115F) were identified in 1 patient.This study is the first to report HIV-2 viral load and drug resistance mutations in HIV-2 strains from Ghana.
Result: In the ART-experienced patient, 3 major drug resistance mutations (M184V, K65R, and Y115F) were found in both the PBMC and plasma sequences.
Discussion: Major drug resistance mutations M184V, K65R, and Y115F were detected in an ART-experienced patient.
Discussion: The occurrence of Y115F, abacavir-induced mutation, together with M184V, which reduces the susceptibility of lamivudine (3TC
A viral genome wide association study and genotypic resistance testing in patients failing first line antiretroviral therapy in the first large countrywide Ethiopian HIV cohort.
Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.
PMID: 31430369
2019
The Journal of antimicrobial chemotherapy
Method: Primary NRTI-R substitutions were M41L, K65R/E/N, D67N, T69 insertions, K70E/R, L74V/I, Y115F, Q151M, M184V/I, L210W, T215Y/F and K219E/Q/N/R in RT.
Table: Y115F
HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.
PMID: 31885806
2019
Oxidative medicine and cellular longevity
Result: The most frequent mutation of resistance to NRTI worldwide is M184V/I, followed by K65R/N, L74V/I, Y115F, and Q151M, and the most prevalent for FSU_A is M184V, followed by K65R/N.
HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.
Method: Antiviral assays (p24 assay) using wild-type HIV-1 (HIV-1WT) and replicable HIV-1 variants (HIV-1Q151M, HIV-1Q151M/Y115F/F116Y, and HIV-1Q151M/I63V/L74V) were also conducted as previously described.
Result: Critically, EFdA activity against HIV-1Q151M and HIV-1Q151M/Y115F/F116Y increased (IC50: 30 pM for both variants) when compared to that against HIV-1WT (IC50: 0.4 nM).
Result: Furthermore, the anti-HIV-1 activity of ETV drastically improved in the presence of Q151M and additional mutations Y115F and F116Y; the IC50 numbers of ETV against HIV-1Q151M and HIV-1Q151M/Y115F/F116Y decreased to
HIV-1 genetic diversity, geographical linkages and antiretroviral drug resistance among individuals from Pakistan.
Abstract: The remaining 7% of the sequences contained a major mutation, Y115F, which causes the virus to exhibit low to intermediate resistance against lamivudine and emtricitabine.
Distinct Pattern of Thymidine Analogue Mutations with K65R in Patients Failing Tenofovir-Based Antiretroviral Therapy.
PMID: 29084434
2018
AIDS research and human retroviruses
Introduction: Also common were associated DRMs K70E and Y115F.
Introduction: As expected, patients failing AZT-based therapy did not develop mutations K65R, K70E, L74V, or Y115F, and only rarely were DRMs from the Q151M complex seen.
Short Communication: Discordance in Drug Resistance Mutations Between Blood Plasma and Semen or Rectal Secretions Among Newly Diagnosed HIV-1-Infected Thai Men Who Have Sex with Men.
PMID: 29756454
2018
AIDS research and human retroviruses
Abstract: Three participants had DRAMs in anogenital compartments that were not detected in blood plasma-one had DRAMs in semen that was not detected in blood plasma (I54FI) and two had DRAMs in rectal secretions that was not detected in blood plasma (I47IM; K70N, L74I, Y115F, M184V, K103N, V108I, and H221Y).
Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana.
Result: The major DRAMs to NRTIs seen in this group were M184 V, Y115F, K70R, K219E and M41 LM while the minor DRAMs to NRTIs seen were T215S, T215I and D67G.
HIV mutation literature information.
PMID: 
2019
Biochemical and biophysical research communications
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