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Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis.
PMID:
8861970
1996
The EMBO journal
Abstract:
The substitution of
Tyr115 by Phe
renders a fully active
polymerase
, displaying similar kinetic parameters, processivity and misinsertion fidelity of DNA synthesis as the wild-type enzyme.
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Y115F
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8861970
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34819737
34694877
34622871
34584606
34484134
34377002
34327247
34243716
34076480
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34025122
33654530
32993693
32804970
32694410
32280691
32265875
32183889
32119691
32105319
32102660
32080249
32041622
32005262
31965175
31885806
31430369
31262272
31117863
30732150
30648556
30442114
30391482
30223845
30174310
30079168
29846534
29756454
29374261
29084434
29074854
29049402
28942522
28891788
28750647
28365230
28129253
28086929
27368990
27231099
27092551
26717411
26558396
26147742
26010948
25754408
25659108
25630709
25557601
25259833
24760888
24633208
24583671
24444369
23985909
23904291
23840622
23717585
23187937
23079810
22805180
22448246
22330916
22132100
20462946
20008905
19644383
18728003
18505170
17500586
17457088
17417971
17403997
17057610
17020946
16982781
16436719
15880183
15616314
15544690
15047556
12176989
10864662
10737786
10720512
10708287
10103184
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HIV mutation literature information.
PMID: 
1996
The EMBO journal
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Co-occurred Entities
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