literature

HIV mutation literature information.

Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data.

PMID: 23436985 2013 PLoS computational biology

Result: Some mutations are slightly underestimated, these include V90I and V106I.

Resistance to the most recent protease and non-nucleoside reverse transcriptase inhibitors across HIV-1 non-B subtypes.

PMID: 23629015 2013 The Journal of antimicrobial chemotherapy

Abstract: For etravirine, only G190A was more prevalent in B than non-B subtypes, whereas V90I and V179E were more frequent in non-B than B subtypes.

Abstract: For rilpivirine, V108I and Y188I were more frequent in B than non-B subtypes, whereas V90I was more prevalent in non-B subtypes.

Description of HIV-1 group M molecular epidemiology and drug resistance prevalence in Equatorial Guinea from migrants in Spain.

PMID: 23717585 2013 PloS one

Table: V90I

HIV-1 drug-resistance surveillance among treatment-experienced and -naive patients after the implementation of antiretroviral therapy in Ghana.

PMID: 23977189 2013 PloS one

Result: However, polymorphisms at NNRTI-resistance mutation loci, V90I, E138A, and V106I, were found in 6 cases (10.2% in Table 4).

Result: This case possessed HIV-1 RT mutations M41L, V90I, A98G, M184V and T215Y, and the major NFV-resistance mutation L90M in PR.

Table: V90I

The impact of HIV-1 reverse transcriptase polymorphisms on responses to first-line nonnucleoside reverse transcriptase inhibitor-based therapy in HIV-1-infected adults.

PMID: 24157905 2013 AIDS (London, England)

Abstract: Polymorphisms associated with virologic failure occurred at codons 90 (mostly V90I), 98 (mostly A98S), and 103 (mostly K103R), with adjusted hazard ratios of 1.78 (1.15-2.73; P = 0.009), 1.55 (1.16-2.08; P = 0.003), and 1.75 (1.00-3.05: P = 0.049), respectively.

Monitoring HIV viral load in resource limited settings: still a matter of debate?

PMID: 23236346 2012 PloS one

Table: V90I

Virological failure rates and HIV-1 drug resistance patterns in patients on first-line antiretroviral treatment in semirural and rural Gabon.

PMID: 23199801 2012 Journal of the International AIDS Society

Result: Five additional viruses were predicted to be possibly resistant to ETV, including three viruses harbouring the E138A/G/Q/R DRM, one with the three DRMs K101E/H/I/P/R, Y181C, and G190A/S, and one with the three DRMs V90I, K101E/H/I/P/R, and G190A/S.

Result: Major NNRTIs DRMs were also obtained at positions P225H (n=12), K101E (n=11), Y181C (n=10), G190A (n=7), Y188L (n=6), V90I (n=5),

PMID: 22337292 2012 Journal of medical virology

Abstract: The most prevalent ETR RAMs observed were L100I, V90I, and K101E, with a prevalence of 16.4% (n = 9), 9.1% (n = 5), and 5.5% (n = 3), respectively.

Molecular epidemiology of HIV in two highly endemic areas of northeastern South Africa.

PMID: 22189822 2012 Archives of virology

Discussion: Among the RT sequences, 2 of the 44 viruses (4.5%) harbored the K103N substitution, which confers resistance to nevirapine, and it also occurred in combination with V90I in one virus.

Discussion: Other substitutions that were found include V90I, E138A, and V179D, which are weakly associated with decreased NNRTI susceptibility, and V118I, which occurs in ~2% of untreated individuals and with increased frequency in those receiving multiple NRTIs.

Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender, and age issues.

PMID: 21936717 2012 AIDS research and human retroviruses

Abstract: The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and

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