The use of dried blood spot specimens for HIV-1 drug resistance genotyping in young children initiating antiretroviral therapy.
PMID: 26192603
2015
Journal of virological methods
Introduction: Only one specimen was predicted to be resistant to protease inhibitors (PI) due to the presence of major and minor PI mutations (L10F, M46I, I54V, L76V and V82A) while 8 specimens had minor PI mutations (A71T (n=3), L10I/V (n=3) and M46L/T (n=2)).
HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.
Result: The most common major PI DRMs were V82A, I76V, I84V and L47A.
Table: V82A
Discussion: Our analysis suggests that the four mutations V82A, L76V, I84V, and I47A would have a sensitivity approaching 90% for detecting intermediate or high-level LPV resistance and that I50L and N88S are the most common major PI-associated DRMs to develop in individuals with VF and intermediate or high-level ATV resistance on an initial ATV/r-associated regimen.
Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
Introduction: L23I, D30N, E35G, M46I/L/V, G48V, I54L, G73S/T/C/A, T74S, V82A/F/S/T, I84V, N88D/S and L90M are other mutations correlated to NFV resistance.
Introduction: The other mutations which were co-occurring with DBM and TPM included major mutations like- M46IL, I54MV, I84V, L90M, N88S, V32I, PMID: 26572102
2015
BMC infectious diseases
Result: Among PI mutations, M46I (n = 5) was the commonest mutation, followed by N88S (n = 3), I50L (n = 2), I84V (n = 2), V 82A (n = 1).
Table: V82A
The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil.
Abstract: Most common protease mutations were M46I, V82A, I54V, L90M, I84V, M46L, and L76V.
Result: In the experienced subgroup, at least seven major (M46I, V82A, I54V, L90M, I84V, M46L, and L76V) and 15 accessory mutations (I62V, A71V, L10I, L10V, K20R, L33F, PMID: 26157536
2015
The open AIDS journal
Result: The major PI treatment-emergent mutations selected at VF in virus from Patient-1 included M46M/L, I50I/V, I54I/L, and Q58Q/E, while virus from Patient-2 selected the V82V/A mutation.
Discussion: This patient's virus had the major PI mutations M46L, V82A and L90M at baseline, and the I54L mutation emerged during therapy.
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
Systematic molecular dynamics, MM-PBSA, and ab initio approaches to the saquinavir resistance mechanism in HIV-1 PR due to 11 double and multiple mutations.
PMID: 25036111
2014
The journal of physical chemistry. B
Abstract: Herein, we extend our analysis, which includes seven double (G48V-V82A, L10I-G48V, G48V-L90M, I84V-L90M, L10I-V82A, L10I-L63P, A71V-G73S) and four multiple (L10I-L63P-A71V, L10I-G48V-V82A, G73S-I84V-L90M,
Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.
Result: We modelled the proteins with unusual mutations (L5F, D29V, L63G, L63R, P79L and T91V), natural polymorphisms (L63H andL63S), and drug-resistant mutant PRs with single mutations or patterns of mutations (D30N, V32I, M36I, M46I, I47V, G48V, I50V, I50L, I54M, Q58E, T74P,
Table: V82A
Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling.
Result: The POST construct contains 8 additional drug-selected polymorphisms, including L10I, I15V, E34Q (negative to uncharged), M36I, T37N, I54A, R57E (positive to negative), and V82A.
HIV mutation literature information.
PMID: 
2015
Journal of virological methods
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