Treatment Outcomes and Resistance Patterns of Children and Adolescents on Second-Line Antiretroviral Therapy in Asia.
PMID: 27355415
2016
Journal of acquired immune deficiency syndromes (1999)
Result: Data on PI resistance mutations were available among 50 (68%) children, and included any major LPV mutation (L76V, V82A, V82S; 8%), >=6 LPV mutations (2%), any major darunavir (DRV) mutation (I84V, L76V; 2%), and any major ATV mutation (I84V, N88S; 4%) (Table 2).
Drug resistance mutations among virological failure HIV-1 infected patients in Malaysia.
Abstract: The most commonly observed mutations for major PI and minor PI seen among the study population were V82A/T and L10V, respectively.
Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa.
PMID: 26258548
2015
AIDS research and human retroviruses
Introduction: In patient 15, the A431V mutation developed in the NC/p1 cleavage site at failure with major mutation V82A, a coevolution that is frequently observed.
Introduction: The major LPV resistance mutation I54V developed at failure in two patients (6 and 8) and V82A in two additional patients (4 and 15).
Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir.
Abstract: Molecular dynamics simulations are performed to investigate the dynamic properties of wild-type HIV-1 protease and its two multi-drug-resistant variants (Flap + (L10I/G48V/I54V/V82A) and Act (V82T/I84V)) as well as their binding with APV and DRV inhibitors.
Introduction: indicated that the small structure difference of APV and DRV inhibitors lead to apparently different binding affinities towards WT HIV-1 PR and its two multi-drug-resistant (MDR) variants, namely Flap+ (L10I/G48V/I54V/V82A) and Act (V82T/I84V<
Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
Result: Among the 44 sequences with TDR to PIs, the most common mutations were L90M (47.7%), M46L/I (33.3%), I54V/T (21.4%), and V82A (19%).
Result: It is noteworthy that several major mutations associated to high level resistance to NRTIs (K65R, L74V, Y115F, M184V and T215Y), to NNRTIs (l100I, K101E, K103N/S, V106M, Y181C, Y188L and G190A) and
Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.
Abstract: Three patients (5%) had major protease inhibitor (PI) resistance mutations: all three had the V82A mutation, and one patient (Clade J virus) had a concurrent M46I, Q58E, and L76V DRM.
Result: V82A was detected in all three patients, with concurrent M46I, Q58E, and L76V in one of the three patients harboring the clade J HIV-1 virus.
Exploring the drug resistance of V32I and M46L mutant HIV-1 protease to inhibitor TMC114: flap dynamics and binding mechanism.
PMID: 25562662
2015
Journal of molecular graphics & modelling
Introduction: It was found that, the mutations D30N and I50V results in the drug resistance to TMC114; however the changes due to mutations V82A, I84V and L90M are well adapted by TMC114.
Introduction: utilized the crystallographic study to analyze the effectiveness of TMC114 to HIV-1-pr, with highly drug resistant mutants D30N, I50V, V82A, I84V, and L90M.
Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution.
Result: By considering the residues with maximum variations in their orientational correlations that are below the lower standard deviation bound (average minus one standard deviation), it is assessed that the average correlation coefficient value which is 0.45 between NC-p1WT and NC-p1V82A increases to 0.58 between NC-p1WT and AP2VNC-p1V82A in the slowest mode.
Result: Figure4 displays the orientational correlation values of the fluctuation vectors of protease residues of NC-p1V82A and AP2VNC-p1V82A with respect to NC-p1WT for the slowest two modes.
Result: Furthermore, the variations in the fluctuation directions of the hinge residues
Single Genome Analysis for the Detection of Linked Multiclass Drug Resistance Mutations in HIV-1-Infected Children After Failure of Protease Inhibitor-Based First-Line Therapy.
PMID: 25923117
2015
Journal of acquired immune deficiency syndromes (1999)
Abstract: In one child, the majority species contained M184V in reverse transcriptase linked to L10F, M46I/L, I54V, and V82A in PR and a triple-class drug-resistant variant with these mutations linked to the NNRTI mutation V108I.
Abstract: In the second child, the majority species contained M184V and V82A linked within viral genomes.
Discussion: Age adjusted full-dose RTV can select M46I, I54V, and V82A in children, as well as L10F, PMID: 25919760
2015
AIDS research and human retroviruses
Abstract: Major protease resistance mutations (M46I, I54V, and V82A) were identified in eight (40%) patients, as well as Gag cleavage site (CS) mutations (at codons 373, 374, 378, 428, 431, 449, 451, and 453) in nine (45%) patients.
HIV mutation literature information.
PMID: 
2016
Journal of acquired immune deficiency syndromes (1999)
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