Introduction: Following the Stanford algorithm (mutation list), minor resistance mutations (
Discussion: Also, Gag mutation D480E which is recognized as a PI-exposure associated mutation significantly correlated with two major PI/r resistance mutations (I54V and V82A).
Discussion: More precisely, Gag mutation P453L positively correlated with seven major protease resistance mutations (L33F, M46I, I54L, I54V, V82A, V82T, I84V).
Brief Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide Efficacy in Participants With Preexisting Primary Integrase Inhibitor Resistance Through 48 Weeks of Phase 3 Clinical Trials.
PMID: 34897227
2022
Journal of acquired immune deficiency syndromes (1999)
Table: V82A/F
Table: V82A
Diversity of HIV-1 Subtypes and Transmitted Drug-resistance Mutations Among Minority HIV-1 Variants in a Turkish Cohort.
Abstract: M41L, L74I, K65R, M184V, and M184I related to NRTI, K103N to NNRTI, and N83D, M46I, I84V, V82A, L24I, L90M, I54V to the PI sites were identified using NGS.
Emergence of Resistance in HIV-1 Integrase with Dolutegravir Treatment in a Pediatric Population from the IMPAACT P1093 Study.
PMID: 34694878
2022
Antimicrobial agents and chemotherapy
Table: V82A
Characterization of HIV-1 drug resistance among patients with failure of second-line combined antiretroviral therapy in central Ethiopia.
Abstract: Most common mutations were M184V (57.1%), Y188C (25.7%), M46I/L (25.7%) and V82A/M (25.7%).
Increased acquired protease inhibitor drug resistance mutations in minor HIV-1 quasispecies from infected patients suspected of failing on national second-line therapy in South Africa.
Abstract: Several RTI RAMs, such as K65R, M184V or K103N and PI RAM V82A, were identified in < 20% of the population.
Abstract: The majority of the drug resistance mutations in the minor viral quasispecies were observed in the V82A mutation (n = 13) in protease and K65R (n = 5), K103N (n = 7) and M184V (n = 5) in reverse transcriptase.
Result: Most of the DRMs in the minor viral quasispecies were observed in V82A mutation (n = 13) in protease and K65R (n = 5),
Understanding the co-evolutionary molecular mechanisms of resistance in the HIV-1 Gag and protease.
PMID: 34253143
2021
Journal of biomolecular structure & dynamics
Abstract: Here we showed that distinct changes in PR's active site, flap and elbow regions due to several PR resistance mutations (L10F, M46I, I54V, L76V, V82A) were found to alter LPV and DRV drug binding.
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.
Abstract: The DRMs most frequent were M184I/V (82.9%) for nucleoside reverse transcriptase inhibitors (NRTI), K103N/S (63.4%) for nonnucleoside reverse transcriptase inhibitor (NNRTI), and V82A/L/M (7.3%)
Result: Only half of the individuals had used PI (n = 46/82), only 17% of individuals presented DRMs associated with protease inhibitors (n = 14), and the most frequent mutations were V82A/L/M (6/82; 7.3%) and I54L/M/V (5/82; 6%), L90M (4/82; 4.8%), and M46L/I (4/82; 4.8%) (Figure 1).
Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.
PMID: 34069929
2021
International journal of molecular sciences
Result: SDRM in PR were found in 5021 (24.82%) sequences and the more frequent were V82A (9.99%, n = 2021), M46I (9.58%, n = 1938), and I54V (8.50%, n = 1719).
Result: The SDRM with most similar prevalence when comparing both groups were M46I, V82A, L90M and I54V.
Molecular Network Analysis Reveals Transmission of HIV-1 Drug-Resistant Strains Among Newly Diagnosed HIV-1 Infections in a Moderately HIV Endemic City in China.
Discussion: Only I54L (n = 1), V82A (n = 1), and L90M (n = 5) conferred low or intermediate resistance to LPV/r, suggesting that the low prevalence of these TDRs is related to the fact that LPV/r is not widely used as a second-line drug in China.
HIV mutation literature information.
PMID: 
2022
Scientific reports
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