Abstract: Two epitope variants, RASVLSGGK and RASILSGGK containing the
V7I mutation, were identified using the iTopia Epitope Discovery System, however only the consensus variant (RAK9C) was confirmed using the ELISpot assay and it represents a novel A*0301 epitope.
Abstract: Using this approach we identified/confirmed the predicted HLA-A*0301 epitopes in two regions of
gag containing PS mutations
V7I and
K403R, one previously reported and the other novel.
Introduction: Our previous study of HIV-1
gag in a large
HIV-1-infected cohort (N=431) identified three positively selected (PS) amino acids,
V7I and
I34L in the p17 region of
gag (unpublished) and
PMID: 17417971
2007
Retrovirology
Table: V7I
HIV mutation literature information.
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