literature

HIV mutation literature information.

HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M.

PMID: 25397483 2014 Journal of the International AIDS Society

Abstract: not described in HIV-M) F121C (HIV-O/B for RAL), V75I (HIV-O/A for RAL) and S153V (HIV-O/A for DTG).

The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.

PMID: 25341667 2014 Viruses

Introduction: Q151 is mutated to methionine (Q151M) in response to treatment with dideoxynucleoside analogs and usually occurs in combination with A62V, V75I, F77L, and F116Y mutations.

Introduction: The Q151M complex consists of five mutations (Q151M/A62V/V75I/F77L/F116Y), of which Q151M is one of the primary mutations to emerge.

HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia.

PMID: 25141905 2014 Journal of the International AIDS Society

Introduction: Q151M is usually accompanied by the mutations A62V, V75I, F77L and F116Y.

2014 Update of the drug resistance mutations in HIV-1.

PMID: 25101529 2014 Topics in antiviral medicine

Discussion: Q151M is the most important mutation in the complex (ie, the other mutations in the complex [A62V, V75I, F77L, and F116Y] in isolation may not reflect multidrug resistance).

HIV-1 drug mutations in children from northern Tanzania.

PMID: 24729604 2014 The Journal of antimicrobial chemotherapy

Table: V75I/V

Table: V75I

Drug resistance in HIV patients with virological failure or slow virological response to antiretroviral therapy in Ethiopia.

PMID: 24708645 2014 BMC infectious diseases

Discussion: In a study conducted in Gondar, only two mutations (V75I and G190A) were detected among 92 ART-naive patients in 2003, before ART roll out.

Increased risk of Q151M and K65R mutations in patients failing stavudine-containing first-line antiretroviral therapy in Cambodia.

PMID: 24015311 2013 PloS one

Result: In our study, other NRTI-RAMs known to be associated with Q151M-mediated multi-nucleoside resistance including A62V, V75I, F77L, and F116Y, were also significantly more common in patients harboring the Q151M mutation (p<0.001).

Major groove binding track residues of the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase enhance cDNA synthesis at high temperatures.

PMID: 24303887 2013 Biochemistry

Abstract: Some of them (e.g., F61A, K65R, K65R/V75I, and V148I) had a negative effect on reverse transcription efficiency above 65C.

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis.

PMID: 23444139 2013 Nucleic acids research

Result: All tested RTs showed similar or increased catalytic efficiencies (measured as the ratio kcat/Km) in comparison with the O_WT RT, and the mutant enzyme V75I (O_V75I), as well as with the BH10_WT RT.

Result: Although position +149 could be considered as a common hot spot location for both mutant RTs, identified errors were one-nucleotide deletions in the case of O_V75I/D443N RT and base substitutions (mostly G T mutations) in the case of O_V75I/E478Q RT.

Result: For example, the spectrum of O_D443N

PMID: 23840622 2013 PloS one

Method: The Q151M complex of mutations was defined as Q151M alone or in combination with one or more of the following mutations: A62V, V75I, F77L, and F116Y.

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