Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.
PMID: 22977160
2013
The Journal of antimicrobial chemotherapy
Abstract: Besides I50L, four PR mutations previously associated with protease inhibitor resistance (I54L, I64V, V71I and I82F) and six PR mutations of unknown impact (V10I, E37D, S43T, K45R, I75V and F85L) in HIV-2 were also identified in this small group of patients.
Complex patterns of protease inhibitor resistance among antiretroviral treatment-experienced HIV-2 patients from Senegal: implications for second-line therapy.
PMID: 23571535
2013
Antimicrobial agents and chemotherapy
Abstract: Common protease substitutions included V10I, V47A, I54M, V71I, I82F, I84V, L90M, and L99F, and most patients harbored viruses containing multiple changes.
Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa.
Result: The contribution of individual HIV-2 PR mutations that confer phenotypic resistance to PIs have not been delineated; however, the emergence of mutations (K7R, G17N, K45R, M46I, V47A, I54M, V62A, I64V, V71I, I82F/L, I84V, L90M, and L99F) in PR in HIV-2 from individuals receiving PI-based therapy have been observed in previous studies.
Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database.
Abstract: The most frequent mutations selected under therapy (compared to HIV-2 ROD) were V71I, L90M and I89V within PR.
Antiretroviral drug-resistant HIV-2 infection--a new therapeutic dilemma.
PMID: 17062187
2006
International journal of STD & AIDS
Abstract: Mutations at codons M184V and Q151M conferring resistance to nucleoside reverse transcriptase inhibitors (NRTIs) in HIV-1 infection were detected, as were mutations at codons V71I and L90M implying indinavir and nelfinavir resistance as well.
Polymorphism and drug-selected mutations in the protease gene of human immunodeficiency virus type 2 from patients living in Southern France.
PMID: 14766818
2004
Journal of clinical microbiology
Abstract: In addition, at six positions (positions 7, 46, 62, 71, 90, and 99), the amino acid variability or the amino acid frequencies or both differed significantly in PI-treated and untreated patients, suggesting that mutations 7K-->R, 46V-->I, 62V-->A/T, 71V-->I, 90L-->M and 99L-->F were occurring under PI-selective pressure.
HIV mutation literature information.
PMID: 
2016
BMC infectious diseases
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