Analysis of HIV type 1 gp41 and enfuvirtide susceptibility among men in the United States who were HIV infected prior to availability of HIV entry inhibitors.
PMID: 19552592
2009
AIDS research and human retroviruses
Introduction: The mutations analyzed included (1) mutations in HR1 that are associated with a >10-fold reduction in most clinical isolates and site-directed mutants (major mutations: G36D/E, V38A/E, Q40H, and N43D), (2) other ENF resistance mutations in HR1 (G36S/V, I37V, V38G/M, N42T, N43K, L44M, and L45M), (3) N42S, a natural polymorphism in HR1 that has been associated with ENF hypersusceptibility, and (4) HR2 accessory mutations (N126K, E137K, and S138A).
Altered bystander apoptosis induction and pathogenesis of enfuvirtide-resistant HIV type 1 Env mutants.
PMID: 19619009
2009
AIDS research and human retroviruses
Abstract: The viruses were found to have apoptosis-inducing activity in the order WT > V38M > V38A > G36D > V38E, which correlated with cell-to-cell fusion but not infection.
Introduction: As seen in figure 4, V38E and V38A along with G36D replicated faster and to higher levels than WT.
Introduction: In our assay V38E was found to be most resistant to Enfuvirtide and the least pathogenic raising the possibility that perhaps new generation of gp41 inhibitors may be able to select even more divergent and attenuated viruses.
Introduction: In the case of Enfuvirtide resistant viruses also, we saw that while cell to cell fusion was severely affected especially for mutant
Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment.
PMID: 16891628
2006
The Journal of antimicrobial chemotherapy
Abstract: V38A/E were the most represented mutations at all time-points.
Abstract: CONCLUSIONS: Specific enfuvirtide resistance mutations (V38A/E) are associated with a sustained CD4 increase, without remarkable effects upon viraemia.
Abstract: The presence of V38A/E was significantly associated with a 4.5-fold CD4 increase from baseline to week 24 and with a 6-fold increase at week 36 (P = 0.004 and 0.02 compared without V38A/E, respectively), without significant correlation with viraemia.
In vitro generation of HIV type 1 subtype C isolates resistant to enfuvirtide.
PMID: 16218801
2005
AIDS research and human retroviruses
Abstract: All subtype C isolates showed evidence of genotypic changes in gp41 HR-1 following exposure to ENF that included G36S/E/D, I37T, V38M/A/L/E, N/S42D, N43K, L45R/M, and A50T/V.
HIV-1 resistance to the gp41-dependent fusion inhibitor C-34.
HIV mutation literature information.
PMID: 
2009
AIDS research and human retroviruses
Browser Board
Co-occurred Entities
Filtrator
ViMRT