literature

HIV mutation literature information.

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.

PMID: 29017536 2017 Retrovirology

Conclusion: We have previously found that three other reversion mutations (V247I and T242N in Gag as well as I64T in Tat) also did not cause detectable fitness differences.

Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.

PMID: 25028937 2014 PloS one

Figure: Impact of the V247I or G248A mutation alone on the fitness of their cognate T/F virus.

Figure: Peptides containing T242N, V247I or G248A mutation alone as well as in various combinations were analyzed.

Figure: The fitness impact of the V247I or G248A mutation alone was determined by comparing the mutant

Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation.

PMID: 25407514 2014 Retrovirology

Result: The V247I mutation was selected by T cell responses before the T242N T cell escape mutation in CH77 which had Val at position 247.

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome.

PMID: 23110705 2012 Retrovirology

Abstract: A principal TW10 escape mutation, T242N, led to a 42% reduction in replication fitness but V247I and G248A mutations in the same epitope restored fitness to wild-type levels.

Method: The gag amplicon was amplified by the primers A1-lower: 5' Acry-AGGGGTCGTTGCCAAAGAGTGA-3' (nt 2260-2281) and A1-upper: 5'-CACAGGAACAAGCAGCCAGGTC-3', and the amplicons were annealed with the sequencing primer C1548A: 5'-AAGGGGAAGTGATATAGCAGGATCTACTAGTA-3' (nt 1482-1513) to detect the T242N

Figure: The TW10 CTL epitope region (indicated by a red box) was enlarged to better show the nucleotide identities at three sites (T242N, V247I and G248A) in the viral population (right panel).

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