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 HIV mutation literature information.


  HIV-1 molecular epidemiology and drug resistance-associated mutations among treatment-naive blood donors in China.
 PMID: 32371875       2020       Scientific reports
Table: V179T


  The characteristics of pretreatment HIV-1 drug resistance in western Yunnan, China.
 PMID: 32381145       2020       Epidemiology and infection
Abstract: E138A/G/K/R (14.3%, 46/322) and V179E/D/T (13.7%, 47/322) were the predominant DRMs.
Result: The drug resistance-associated mutations are shown in Table 2, among which E138A/G/K/R (14.3%, 46/322) and V179E/D/T (13.7%, 47/322) were far higher than the others.
Table: V179E/T


  HIV-1 Genetic Diversity and High Prevalence of Pretreatment Drug Resistance in Tianjin, China.
 PMID: 32539490       2020       AIDS research and human retroviruses
Abstract: The most frequent mutation pattern against NNRTIs was V179D/E/T (6.9%, 21/305), with M184V (1.0%, 3/305) and K65R (1.0%, 3/305) against nucleoside RT inhibitors (NRTIs).


  Antiretroviral drug resistance mutations among patients failing first-line treatment in Hanoi, Vietnam.
 PMID: 31190911       2019       Infection and drug resistance
Table: V179T


  Prevalence of HIV-1 pre-treatment drug resistance in a southern province of Iran, 2016-2017.
 PMID: 28983848       2018       Archives of virology
Abstract: Two other DRMs, including E138A (9.7%) and V179T (4.9%), which confer resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs), were also identified.


  Comparison of antiretroviral drug resistance among treatment-naive and treated HIV-infected individuals in Shiraz, Iran.
 PMID: 28986714       2018       Archives of virology
Abstract: V179T causes high level resistance to Efavirenze and Nevirapin.
Abstract: Among treatment-naive, the detected NRTI and NNRTI resistance mutations were V179T, V75 M and E138A.


  Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.
 PMID: 29977795       2018       African journal of laboratory medicine
Result: Among the minority NNRTI mutations, V108I, V179T were detected in four samples and G190A, H221Y and K101E were detected in three samples.
Result: The common minority NNRTI mutations detected were V106M, V179T and G190A (3/20 each), followed by E138K and Y181C (2/20 each), and K101P, K103N, V108I, E138A, V179D, A190E and  PMID: 29739342       2018       BMC infectious diseases
Result: For NNRTI resistance-associated mutations, V179D/T was identified as the major mutation (20 cases), and the other 6 types of mutation were E138A, A98G, K101P, K103 N, Y181H and Y188H.
Discussion: L33F and V179D/T are the types of mutation that confer potential low-level resistance.
Discussion: Even considering the previous report of occurrence in Hebei and Beijing, the mutation rate of V179D/T up to 6.92% is still an astonishing level.


  Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.
 PMID: 29049402       2017       PloS one
Table: V179T


  Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
 PMID: 28891788       2017       HIV clinical trials
Method: Primary NNRTI-R substitutions assessed were V90I, A98G, L100I, K101E/H/P, K103N/S, V106A/I/M, V108I, E138A/G/K/Q/R, V179D/F/L/T, Y181C/I/V, Y188C/H/L, G190A/E/Q/S, H221Y, P225H, F227C, and M230I/L in RT.



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