literature

HIV mutation literature information.

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.

PMID: 34762770 2021 Journal of the International AIDS Society

Result: Only five samples were identified that had low-frequency NNRTI-associated polymorphisms or mutations not previously detected by Sanger sequencing, with the mutant frequency indicated in parentheses: K101R (1.4%), V108I (1.7%), E138A (9.3%), V179G (1.0%) and Y181C (1.2%).

Table: V179G

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.

PMID: 26850643 2016 Nucleic acids research

Result: However, in subtype B the MR-RT exchange V179 to Gly (V179G) has not been found (http://hivdb.stanford.edu/).

Transmitted drug resistance to rilpivirine among antiretroviral-naive patients living with HIV from northern Poland.

PMID: 24746180 2014 Journal of the International AIDS Society

Abstract: RPV-associated mutations were divided into RPV resistance mutations (K101E/P, E138A/G/K/Q/R, V179L, Y181C/I/V, Y188L, H221Y, F227C and M230I/L) according to the International AIDS Society-USA (IAS-USA) mutation list and variants potentially affecting RPV susceptibility (L100I, K101H/T, E138S, V179F/D/G/T, G190A/E/S, F227L and M230V) based on the

Compilation and prevalence of mutations associated with resistance to non-nucleoside reverse transcriptase inhibitors.

PMID: 19320243 2009 Antiviral therapy

Abstract: These included V90I, A98G, L100I, K1O1E/P/Q, K103H/N/S/T, V106A/I/M, V108I, E138G/K/Q, V179D/E/F/G/I, Y181C/I/V, Y188C/H/L, V189I, G190A/C/E/Q/S, H221Y, P225H, F227C/L, M230I/L, P236L, K238N/T and Y318F

Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.

PMID: 17417971 2007 Retrovirology

Table: V179G

In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor.

PMID: 16472877 2006 Antiviral research

Abstract: Results demonstrate that HIV-1 variants selected at increasing CPV concentrations contained multiple substitutions in diverse patterns including L100I, Y181C, G190E and/or L234I in various combinations with K101R/E, K103T, V106A/I, V108I, E138K, T139K, A158T, V179D/I/G, Y188D, V189I, G190A, F227C, W229R, L234F,

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