Result: Among the 37 screen failures, the most common reason for failure was presence of an exclusionary RAM at screening (n = 19; most common were K103N [5] and V179E/I/V [4]).
Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations.
PMID: 26651266
2016
AIDS research and human retroviruses
Method: In addition, we defined a list of minor RPV-RAMs that have been observed in in vitro or in vivo selection studies and are included in one or more of clinically widely used genotypic resistance interpretation algorithms ANRS (V24), Rega (V9.1.0), and HIVdb (V7.0.1), encompassing V90I, A98G, L100I/V, K101H/Q/T, K103R/S, V106A/I, V108I, E138S, V179D/E/F/I/T, Y181F/G/S, Y188F, V189I, G190A/C/E/Q/S/T/V, and M230V
Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.
Result: Furthermore, we tested RMNC6 against several mutants conferring resistance to NNRTIs such as K103N, Y181C and Y188L, and against the HIV-1 group O RT which shows natural resistance to NNRTIs due to the presence of the amino acid substitutions A98G, V179E and Y181C (S2 Appendix).
Evolutionary Dynamics and Complicated Genetic Transmission Network Patterns of HIV-1 CRF01_AE among MSM in Shanghai, China.
Abstract: Besides, a significant transmission of viruses with drug resistant mutations at V179D/E were found in the networks.
Result: Clearly, Among 1, 152 Shanghai CRF01_AE, the proportion of V179D/E was 7
Discussion: An interesting observation in this study was that V179D/E, an NNRTI-associated mutation was dominating Shanghai MSM.
Discussion: Besides, we found a higher proportion of V179D/E mutation in Shanghai CRF01_AE strains than in all others China CRF01_AE strains.
Discussion: Sequences with V179D/E were distributed and networked in most sub-lineages in SH-L1, suggesting that several independent CRF01_AE strains with V179D/E were involved in ongoing transmission in this city.
Characterization of two HIV-1 infectors during initial antiretroviral treatment, and the emergence of phenotypic resistance in reverse transcriptase-associated mutation patterns.
Discussion: Additionally, Y181C did not modify resistance of T215Y/V179E to d4T and led to an increase in the mean IC50 value from 240.77 +- 34.68 nM for T215Y/V179E to 622.10 +- 82.10 nM for the triple-mutation with respect to 3TC.
Discussion: At the end of the current investigation, we found that the mutation at 179 exited stably with V179E, but not initially with V179D.
Discussion: But resistance to EFV of T215Y/V179E is not significant in our study.
Discussion: For EFV, only Y181C increased the IC50 in a T215Y/
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
Result: There were no treatment-emergent NRTI or PI mutations although a treatment-emergent NNRTI polymorphism V179V/D/E was detected.
Prevention of mother-to-child HIV-1 transmission in Burkina Faso: evaluation of vertical transmission by PCR, molecular characterization of subtypes and determination of antiretroviral drugs resistance.
Abstract: Genetic mutations were also isolated that induce resistance to ARV such as M184V, Y115F, K103N, Y181C, V179E, and G190A.
Introduction: have already emphasized the context by which PMTCT led to resistance mutations induced by nevirapine (NVP; V8IV, K103N, V179E, and Y181C).
Table: V179E
Viral Genetic Diversity and Polymorphisms in a Cohort of HIV-1-Infected Patients Eligible for Initiation of Antiretroviral Therapy in Abuja, Nigeria.
PMID: 25582324
2015
AIDS research and human retroviruses
Result: Among all the mutations detected, T74S (54.5%) in PR and E138A (17%), V179I (16%), followed by V118I
Discussion: Subtype G, CRF43-02G, and CRF06-cpx viruses utilized the codon GTG/GTA to encode valine and more likely to develop V179E mutations, whereas other CRF viruses are biased toward V179I and V179D.
Discussion: This pattern of amino acid substitution by a single nucleotide change is called quasisynonymy; it may explain the high rate of the V179E found in subtype G and CRF06-cpx in this cohort and is concordant with published data and statistics predicting the occurrence of this mutation at RT position 179 of these viruses.
HIV mutation literature information.
PMID: 
2016
PloS one
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