Result: The NNRTI-associated mutations were K101Q (1), K103N (4), V179E (1), Y181C (1), Y188L (2), G190A (2) (Table 3).
Table: V179E
Comparison of predicted susceptibility between genotype and virtual phenotype HIV drug resistance interpretation systems among treatment-naive HIV-infected patients in Asia: TASER-M cohort analysis.
8Discussion: The 5-level Stanford HIVdb predicted ""potential low-level resistance"" in all sequences with discordant efavirenz interpretation containing V179D/E."
Abstract: The 68/75 patients with discordant efavirenz results harboured the V179D/E mutations compared to 7/1226 with no efavirenz discrepancy (p-value <0.001).
Abstract: When interpreti
Discussion: V179D/E are often found in treatment-naive individuals infected with non-B subtypes .
Discussion: The RAMs associated with efavirenz discrepancy were V179D/E.
Discussion: Therefore, the significance of V179D/E found in this study should not be interpreted as the cause of the differences between the two interpreting systems, but merely reflects the mutation pattern based on the Stanford HIVDR list.
HIV-1 drug resistant mutations in chronically infected treatment naive individuals in the pre-ARV era in Nigeria.
PMID: 23678638
2012
African journal of medicine and medical sciences
Abstract: Ten of the 64 (15.6%) samples with positive PCR had mutations for PR inhibitors (PI) including R8D, I 15V, G16E, M36I, M46L, L63P and H69K, while 5 of 63 harbored RT inhibitor (NRTI/NNRTI); V179I, A98T, V179E and A98S.
Impact of HIV-1 group O genetic diversity on genotypic resistance interpretation by algorithms designed for HIV-1 group M.
PMID: 21233638
2011
Journal of acquired immune deficiency syndromes (1999)
Abstract: RESULTS: All HIV-O samples naturally exhibited the A98G and V179E resistance mutations in the reverse transcriptase region; 54% of samples presented the Y181C mutation, conferring resistance to nonnucleoside reverse transcriptase inhibitors.
Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes.
PMID: 21135184
2011
Antimicrobial agents and chemotherapy
Abstract: The results show that ETR selected mutations at positions V90I, K101Q, E138K, V179D/E/F, Y181C, V189I, G190E, H221H/Y, and M230L and that E138K was the first of these to emerge in most instances.
Abstract: We identified K101Q, E138K, V179E, V189I, G190E, and H221Y as mutations not included among the 17 currently recognized resistance-associated mutations for ETR.
Compilation and prevalence of mutations associated with resistance to non-nucleoside reverse transcriptase inhibitors.
Abstract: These included V90I, A98G, L100I, K1O1E/P/Q, K103H/N/S/T, V106A/I/M, V108I, E138G/K/Q, V179D/E/F/G/I, Y181C/I/V, Y188C/H/L, V189I, G190A/C/E/Q/S, H221Y, P225H, F227C/L, M230I/L, P236L, K238N/T and Y318F
HIV drug resistance pattern among HAART-exposed patients with suboptimal virological response in Ouagadougou, Burkina Faso.
PMID: 18667925
2008
Journal of acquired immune deficiency syndromes (1999)
Abstract: Some resistance mutations, notably D67N/G, K70R and L210W (thymidine analogue mutations-TAMs); K101E, V179E in RT, 154V, V82A/T/F and L90M in PR were significantly higher among CRF06_cpx than CRF02_AG strains (P < 0.05).
Characterization of HIV type 1 reverse transcriptase mutations in infants infected by mothers who received peripartum nevirapine prophylaxis in Jos, Nigeria.
PMID: 18160018
2007
AIDS research and human retroviruses
Abstract: Four of 13 (31%) infants had NNRTI resistance mutations--V179I (2 infants), Y181C, and V179E.
Variability of the human immunodeficiency virus type 1 polymerase gene from treatment naive patients in Accra, Ghana.
HIV mutation literature information.
PMID: 
2012
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