Drug Resistance to HIV-1 Integrase Inhibitors Among Treatment-Naive Patients in Beijing, China.
PMID: 35300056
2022
Pharmacogenomics and personalized medicine
Result: The most common non-nucleoside reverse transcriptase inhibitors (NNRTIs) associated mutation was V179D (4.97%, 43/865), followed by V179E (4.05%, 35/865) and V106I (2.89%, 25/865).
Pretreatment drug resistance in people living with HIV: A large retrospective cohort study in Chongqing, China.
Abstract: The predominant DRMs for non-nucleoside reverse transcriptase inhibitors (NNRTIs) and nucleoside reverse transcriptase inhibitors (NRTIs) were V179D/E/A/DIN (13.60%) and M184V/I (1.44%), respectively, whereas only two major DRMs (M46L and I54L) were identified for protease inhibitors (PIs).
Pre-existing singleton E138A mutations in the reverse transcriptase gene do not affect the efficacy of first-line antiretroviral therapy regimens using rilpivirine in human immunodeficiency virus-infected patients.
Phase 2 Open-Label Study of Long-Term Safety, Tolerability, and Antiviral Activity of Rilpivirine in Antiretroviral-Naive Adolescents Living with HIV-1.
PMID: 34871089
2022
Antimicrobial agents and chemotherapy
Method: Patients with previously documented HIV-2 infection, with active AIDS, and with documented genotypic evidence of >=1 NNRTI resistance-associated mutation (RAM) from a predefined list of the following NNRTI RAMs at screening were excluded: A98G, L100I, K101E, K101P, K101Q, K103H, K103N, K103S, K103T, V106A, V106M, V108I, E138A, E138G,
Transmitted drug resistance and transmission clusters among HIV-1 treatment-naive patients in Guangdong, China: a cross-sectional study.
Discussion: The most frequent NNRTI-associated SDRM in our study was K103N, while it is V179E and V106I in Southwest China and K103N/S and E138A in Iceland and the south-central United States.
HIV-1 molecular transmission network among sexually transmitted populations in Liaoning Province, China.
Result: Among them, 9 cases were protease inhibitor-related resistance, and the main resistance sites were L33F, V82A, Q58E, M46L, M46I; There were 4 cases of nucleoside reverse transcriptase inhibitor resistance, the main mutation sites were V75VI, K219Q, T215A, K65R; There were 5 cases of non-nucleoside reverse transcriptase inhibitor resistance, the main mutation sites were V179E, A98G, V106I, Y181C, G190S
HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.
Abstract: The most common DRMs were M184I/V (42.2%), followed by V179D/E (37.9%) and
Result: The major NNRTI DRMs were V179D/E (37.9%, 149/393), V106I/M (25.7%, 101/393), and K103N/Q (25.2%, 99/393) (Table 3).
Table: V179D/E
Discussion: V179E/D does not appear to reduce the virological response to a first-line EFV-containing regimen.
Discussion: V179E is a nonpolymorphic mutation weakly selected by NVP and EFV.
Discussion: In our study, V179E/D was the most common NNRTI-associated mutation, accounting for 37.9%.
High HIV-1 Virological Failure and Drug Resistance among Adult Patients Receiving First-Line ART for At least 12 Months at a Decentralized Urban HIV Clinic Setting in Senegal before the Test-and-Treat.
Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naive HIV Patients in Southeast China.
PMID: 33679129
2021
Drug design, development and therapy
Result: A total of 12 samples contained 13 NNRTIs-resistance mutations:V106I in 4 samples, V179E, V179D mutations each in 3 samples, E138A mutations in 2 samples and V106M in 1 sample.
Table: V179E
HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.
Abstract: Most cases of TDR were related to resistance to non-nucleoside reverse tr
Result: Individuals infected with the subtypes CRF01_AE and CRF08_BC were the most likely to develop NNTRI-associated mutations; the most common mutations were V179E (7.21%), V179D (3.21%), and V106I (1.91%).
Result: The genotype CRF55_01B was the most likely to harbour V179E mutations.
Discussion: Most V179E mutations were detected in CRF55_01B, and most V179D mutations were detected in CRF01_AE, CRF07_BC, and CRF08_BC subtypes.
Discussion: Mutations related to NNRTI resistance were common, especially V179E (7.21%) and V179D (3.21%).
HIV mutation literature information.
PMID: 
2022
Pharmacogenomics and personalized medicine
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