Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants.
PMID: 27124362
2016
Journal of acquired immune deficiency syndromes (1999)
Introduction: However, in clinical trials individuals on an ETR containing regimen who experienced virological failure were infected with viruses that had a combination of RT mutations including V90I, A98G, L100I, K101E/P, V106I, V179D/F, Y181C/I/V, and G190A/S.
Prevalence of HIV-1 Subtypes and Antiretroviral Drug Resistance Mutations in Nepal.
Abstract: Besides, a significant transmission of viruses with drug resistant mutations at V179D/E were found in the networks.
Result: V179D/E mutation distributed in 26 networks in lineage 1B (n = 8), 1C (n = 33), lineage 2 (n = 3), and small lineage (n = 9).
Result: Clearly, Among 1, 152 Shanghai CRF01_AE, the proportion of V179D/E was 7.1% (82/1, 152), higher than all other China CRF01_AE (2.7%, 90/3, 291), P < 0.001.
Result: Overall, four main network-related drug resistant mutations (some were non-tansmitted drug resistance mutations) were discovered at V179D/E (n = 53), M46L (n = 15), T69N (n = 8), and P225H (n = 2).
Discussion: An interesting observation in this study was that PMID: 25582324
2015
AIDS research and human retroviruses
Discussion: Subtype G, CRF43-02G, and CRF06-cpx viruses utilized the codon GTG/GTA to encode valine and more likely to develop V179E mutations, whereas other CRF viruses are biased toward V179I and V179D.
Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naive and treated pediatric patients.
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
Result: Nevirapine and efavirenz resistance were predicted in about 1% and 0.5% of virus samples without NNRTI SDRMs as a result of several minimally polymorphic (e.g., A98G, V108I, and V179D) and rare nonpolymorphic (e.g., E138K, G190Q, F227C, and K238T) NNRTI-resistance mutations.
Low prevalence of the transmitted HIV-1 drug resistance among newly diagnosed HIV-1 individuals in Jiangsu Province, China during 2009-2011.
Abstract: RESULTS: Our results show that THDR has been at low level from 2009 to 2011, only K101E and V179D mutation was detected which did not belong to the major HIV-1 drug resistance mutations.
Result: V179D mutation is a borderline/suspicious mutation associated with transmitted HIVDR can reduce the susceptibility of NVP, EFV, and ETR against HIV.
Result: They are K101E and V179D mutation.
Table: V179D
Treatment-Emergent Mutations and Resistance in HIV-Infected Children Treated with Fosamprenavir-Containing Antiretroviral Regimens.
Characterization of two HIV-1 infectors during initial antiretroviral treatment, and the emergence of phenotypic resistance in reverse transcriptase-associated mutation patterns.
Discussion: T215Y, a classical mutation, is suggested to cause AZT and d4T resistance; and V179D/E is considered to be an NNRTI mutation, by itself reducing NVP and EFV susceptibility approximately 2-fold.
Discussion: At the end of the current investigation, we found that the mutation at 179 exited stably with V179E, but not initially with V179D.
Discussion: Herein, T215Y and V179D were observed in plasma first compared to PBMC, as with Y181C.
Discussion: It may be the reason for the phenomenon of V179D/E.
Discussion: This may be another reason for more stable of V179E than
ViMRT
HIV mutation literature information.
PMID: 
2016
Journal of acquired immune deficiency syndromes (1999)
