Transmission Dynamics of HIV-1 Drug Resistance among Treatment-Naive Individuals in Greece: The Added Value of Molecular Epidemiology to Public Health.
Introduction: Resistance to NNRTIs was the most prevalent (16.9%), and our previous analysis revealed that the majority (89%) of NNRTI-resistant viruses (E138A, K103N, and V179D) for subtype A1 belonged to monophyletic clusters (local transmission networks (LTNs)).
Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.
Method: Four subjects on ART also had viruses harboring the NNRTIs secondary mutations V179D, A98G, E138A, V179E, and F227L, including subject NA2CMR151 who had both A98G and the major NNRTI resistance mutation Y181C.
The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014.
Result: 31 specific DRMs were identified from 27 samples with DRMs distributing as: 1) 74.2% (23/31) DRMs were on nonnucleoside reverse transcriptase inhibitors (NNRTIs) as: V179E/D (n = 16), K238N (n = 2),
Table: V179D
Discussion: These two drugs were mostly adopted as first-line NNRTIs for anti-retrovirus treatment (ART) in China.While V179D and E138A mutations were described as polymorphic accessory NNRTI-selected mutation, however, it is unclear whether the V179D and E138A mutations have resulted from drug-specific or natural selective pressure by Chinese population.
HIV-1 viraemia and drug resistance amongst female sex workers in Soweto, South Africa: A cross sectional study.
Comparison of genotypic and virtual phenotypic drug resistance interpretations with laboratory-based phenotypes among CRF01_AE and subtype B HIV-infected individuals.
Result: The two most common NNRTI RAMs were V179D (16%) and V106I (15%); the most common NRTI RAMs were D67N (29%) and M184V (26%); and the most common PI-major RAMs were M46I (11%) and I84V (9%).
Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.
PMID: 26483513
2016
The Journal of antimicrobial chemotherapy
Abstract: BACKGROUND: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain.
Synthesis and Antiviral Evaluation of 1-[(2-Phenoxyethyl)oxymethyl] and 6-(3,5-Dimethoxybenzyl) Analogues of HIV Drugs Emivirine and TNK-651.
Abstract: The newly synthesized non-nucleosides were tested for antiviral activity against wild type HIV-1 IIIB as well as the resistant strains N119 (Y181C), A17 (K103N+Y181C), and the triple mutant EFV(R) (K103R+V179D+P225H) in MT-4 cells.
Prevalence of HIV-1 Subtypes and Antiretroviral Drug Resistance Mutations in Nepal.
Abstract: Besides, a significant transmission of viruses with drug resistant mutations at V179D/E were found in the networks.
Result: V179D/E mutation distributed in 26 networks in lineage 1B (n = 8), 1C (n = 33), lineage 2 (n = 3), and small lineage (n = 9).
Result: Clearly, Among 1, 152 Shanghai CRF01_AE, the proportion of V179D/E was 7.1% (82/1, 152), higher than all other China CRF01_AE (2.7%, 90/3, 291), P < 0.001.
Result: Overall, four main network-related drug resistant mutations (some were non-tansmitted drug resistance mutations) were discovered at V179D/E (n = 53), M46L (n = 15), T69N (n = 8), and P225H (n = 2).
Discussion: An interesting observation in this study was that
ViMRT
HIV mutation literature information.
PMID: 
2017
Genes
