Result: K103R and V179D mutations reduced NVP and EFV susceptibilities by about 10-fold.
Result: V179D/E reduced NVP and EFV susceptibility by about 2-fold.
Result: The drug resistance mutation loci included A71V, D67H, T69N, K70R, T215F, K219E, A98G, V179D, and Y181C, with HNHIV97 and HNHIV113 clustered together.
Table: V179D/E
Table: V179D
Identification of the critical sites of NNRTI-resistance in reverse transcriptase of HIV-1 CRF_BC strains.
Result: Several mutations, including R135L, V179D, Y181C, M184V, K103N, were also present in the treatment-naive patients who were infected by HIV-1 CRF_BC strains, but their frequencies were significantly increased in ART-treated group (P<0.01), while R135L isn't reported to be associated with drug resistance.
Table: V179D
Transmitted drug resistance to rilpivirine among antiretroviral-naive patients living with HIV from northern Poland.
PMID: 24746180
2014
Journal of the International AIDS Society
Method: RPV resistance-associated mutations were divided into key resistance mutations (K101E/P, E138A/G/K/Q/R, V179L,Y181C/I/V, Y188L, H221Y, F227C and M230I/L) based on the IAS-USA drug resistance mutations list update 2013 and potential drug resistance mutations (L100I, K101H/T, E138S, V179F/D/G/T, G190A/E/S, F227L and M230V) based on the clinical trial and in
High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen.
Result: The most common NNRTI mutation in this group was K103N (n = 152, 57.4%) followed by V106M (n = 105, 39.6%), P225H (n = 42, 15.8%) and V179D (n = 29, 10.9%, Figure 1).
Impact of Y181C and/or H221Y mutation patterns of HIV-1 reverse transcriptase on phenotypic resistance to available non-nucleoside and nucleoside inhibitors in China.
Discussion: At the same time, the double mutations were observed along with other NNRTIs including K101E, K101Q, V179D, V179E, K103N, and the viruses were predominant in quasispecies of 6 HIV-1 infected patients in a drug resistance surveillance cohort.
[Resistance evolutionary pathway analysis of HIV-1 CRF_07BC reverse transcriptase].
PMID: 24969455
2014
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Abstract: CONCLUSION: HIV-1 CRF_07BC showed distinctive resistance evolutionary pathway, the mutations K103N,Q197K,V179D and Y188L were the major resistance mutations, and different resistance evolutionary pathways were observed between HIV-1 CRF_07BC and B subtype.
Abstract: RESULTS: The major resistance mutations for CRF_07BC were identified including K103N, Q197K, V179D and Y188L.
Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action.
Result: Because NNRTIs inhibit the excision activity of RT, we next screened each hit for their capacity to inhibit RTs containing the NNRTI resistance mutations K103N, V106A, V179D, Y181C, Y188C or G190A.
The prevalence of transmitted HIV drug resistance among MSM in Anhui province, China.
Result: A98G confers a low level of resistance to EFV and NVP, and while V179D in a URF strain confers a low level of resistance against EFV and an intermediate level of resistance against NVP, V179D in CRF01_AE does not affect resistance to any RT drugs.
Discussion: A98G has been shown to confer low-level resistance against EFV and NVP, and V179D in CRF01_AE/CRF07_BC recombinant viruses has been shown to confer low-level resistance against EFV and intermediate level resistance against NVP, while V179D in CRF01_AE viruses does not affect resistance to any RT drugs (data not published).
2014 Update of the drug resistance mutations in HIV-1.
Discussion: However, for isolates harboring the L100I/ K103N/R/S or V179D as single mutations, no reduction in susceptibility was detected.
Discussion: The combinations of reverse transcriptase mutations L100I + K103N/S and L100I + K103R + V179D were strongly associated with reduced susceptibility to rilpivirine.
HIV-1 transmitted drug resistance-associated mutations and mutation co-variation in HIV-1 treatment-naive MSM from 2011 to 2013 in Beijing, China.
Conclusion: There are significant co-variation pairs between TDR-associated mutations (V179D/E) and seven overlapping polymorphisms among subtype CRF01_AE.
Table: V179D/E
Table: V179D
Discussion: Certainly, further study is needed to determine how the V179D/E-associated polymorphisms affect the replication fitness of CRF01_AE HIV-1 strains.
Discussion: Fifty-seven samples had at least one TDR-associated mutation, mainly including L10I/V (6.3%), A71L/T/V (6.3%), V179D/E (5.4%), and V106I (2.7%), with different distributions of TDR-associated mutations by different HIV-1 subtypes and by sample year.
HIV mutation literature information.
PMID: 
2014
PloS one
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