ViMRT
}  
 
Home   
< Docs   

 HIV mutation literature information.


  HIV-1 drug resistance-associated mutations among antiretroviral-naive Thai patients with chronic HIV-1 infection.
 PMID: 23161095       2013       Journal of medical virology
Abstract: DRAMs to NNRTIs were V106I (7%), V179D (4.2%), V179T (1.8%), E138A (1.5%), V90I (1.2%), K103N (0.9%), Y181C (0.9%), and P225H (0.3%).


  Prevalence of pre-existing resistance-associated mutations to rilpivirine, emtricitabine and tenofovir in antiretroviral-naive patients infected with B and non-B subtype HIV-1 viruses.
 PMID: 23361642       2013       The Journal of antimicrobial chemotherapy
Abstract: We studied the primary rilpivirine RAMs (K101E/P, E138A/G/K/Q/R, V179L, Y181C/I/V, H221Y, F227C and M230I/L) and other potential rilpivirine-associated mutations (V90I, L100I, K101T, E138S, V179D/I, Y188L, V189I, G190A/E/S and M230V).


  Evaluation of etravirine resistance in clinical samples by a simple phenotypic test.
 PMID: 23364785       2013       Journal of medical virology
Abstract: Five NNRTI resistant mutant forms of RT were produced (L100I, K103N, L100I/K103N, Y181C, V179D) in order to validate the assay for ETR.


  Genetic barrier to the development of resistance to rilpivirine and etravirine between HIV-1 subtypes CRF02_AG and B.
 PMID: 23833185       2013       The Journal of antimicrobial chemotherapy
Abstract: Different predominant codons between the subtypes were observed in 5/12 positions (90, 98, 179, 181 and 227), with an effect on the calculated genetic barrier only at the V179D and V179F codons (2.5 versus 3.5 for V179D, and 2.5 versus 5 for V179F, respectively, for subtype B versus subtype CRF02_AG).
Abstract: Nevertheless, subtype CRF02_AG showed a higher genetic barrier to acquiring mutations V179D and V179F (mutations associated with resistance to etravirine) compared with subtype B, suggesting that it would be more difficult to produce resistance to etravirine in the CRF02_AG subtype than the B subtype.


  Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.
 PMID: 23840622       2013       PloS one
Result: Additional NNRTI-resistance mutations not shown in Table 4 included (i) A98G, which occurred in 3.3% of NNRTI-treated patients; (ii) V106A, which occurred in 0.6% of NNRTI-treated patients; (iii) E138G/Q, which occurred in 0.9% and 0.9% of patients, respectively; (iv) V179D/E/T/F, which occurred in 8.5%, 0.7%, 0.5%, and 0% of NNRTI-treated patients respectively; (v) Y181I/V, which occurred in one and no patient, respectively; (vi) H221Y, which occurred in 5.9% of EFV-treated and 9.3% of NVP-treated patients (p<0.001); (vii) P225H, which occurred in 13.6% of EFV-treate


  HIV antiretroviral resistance mutations among antiretroviral treatment-naive and -experienced patients in South Korea.
 PMID: 23952717       2013       AIDS research and human retroviruses
Abstract: Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients.


  Prevalence and mutation patterns of HIV drug resistance from 2010 to 2011 among ART-failure individuals in the Yunnan Province, China.
 PMID: 24009694       2013       PloS one
Result: The frequencies of some mutations, including A71TV, T69S, and V179D were relatively high between the therapy-naive and the ART-failure individuals but the impact on susceptibility to antiviral drugs was low; therefore, these mutations were not described in detail in this study.


  The impact of HIV-1 reverse transcriptase polymorphisms on responses to first-line nonnucleoside reverse transcriptase inhibitor-based therapy in HIV-1-infected adults.
 PMID: 24157905       2013       AIDS (London, England)
Abstract: Polymorphisms at codon 179, especially V179D/E/T, predicted reduced week 4 responses (P = 0.001) but not virologic failure.
Abstract: The mechanisms underlying the slower suppression seen with V179D/E/T deserve further investigation.


  Molecular epidemiology of HIV in two highly endemic areas of northeastern South Africa.
 PMID: 22189822       2012       Archives of virology
Discussion: One of the viruses harbored the combination V118I/E138A/V179D, while another had V118I/E138A.
Discussion: Other substitutions that were found include V90I, E138A, and V179D, which are weakly associated with decreased NNRTI susceptibility, and V118I, which occurs in ~2% of untreated individuals and with increased frequency in those receiving multiple NRTIs.


  Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP.
 PMID: 22536497       2012       AIDS research and treatment
Discussion: In our study, mutation patterns K101Q/H221Y, K101Q, V179D/H221Y, V179D, K103N/H221Y, and K103N, Y181C could, respectively, improve 759.1 +- 41.9, 1297.0 +- 289.1, 390.0 +- 101.6, 312.5 +- 45.3, 41.9 +- 8.4, and 47.9 +- 4.2-fold to NVP resistance.
Discussion: Our study showed that as for the mutation profiles K101Q/Y181C, K101Q, V179D/Y181C, V179D, K103N/Y



Browser Board

 Co-occurred Entities




   Filtrator