Result: For NNRTI resistance-associated mutations, V179D/T was identified as the major mutation (20 cases), and the other 6 types of mutation were E138A, A98G, K101P, K103 N, Y181H and Y188H.
Discussion: L33F and V179D/T are the types of mutation that confer potential low-level resistance.
Discussion: Even considering the previous report of occurrence in Hebei and Beijing, the mutation rate of V179D/T up to 6.92% is still an astonishing level.
Next-generation sequencing provides an added value in determining drug resistance and viral tropism in Cameroonian HIV-1 vertically infected children.
Result: In the control-group, UDPS detected V179D at minority-level (2.9%), a polymorphic accessory mutation selected under EFV, in a child aged 6 years (Table 3).
Discussion: NNRTI mutations (E138A and V179D), found in children without PMTCT-exposure, are known as polymorphisms with little or no effect on drug susceptibility or virological response.
Frequent cross-resistance to rilpivirine among subtype C HIV-1 from first-line antiretroviral therapy failures in South Africa.
Method: Plasma samples contained a median of 3 [Q1-Q3: 2-4] NNRTI-associated drug resistance mutations which included A98G, L100I, K101E/H, K103N/S, V106M, V108I, E138A/K, V179D/E Y181C, Y188L/C, G190A, H221Y, P225H, F227L, and M230L.
The association between detected drug resistance mutations and CD4(+) T-cell decline in HIV-positive individuals maintained on a failing treatment regimen.
Abstract: The detection of any non-nucleoside reverse transcriptase inhibitor resistance, the RT mutations V179D and L74V were associated with steeper CD4 declines.
Prevalence of drug resistance among HIV-1 treatment-naive patients in Greece during 2003-2015: Transmitted drug resistance is due to onward transmissions.
PMID: 28688977
2017
Infection, genetics and evolution
Abstract: For subtype B, 68.1% (139 out of 204) of resistant strains (E138A, K103N, E138Q V179D) belonged to clusters.
Abstract: The majority of subtype A sequences (89.7%; 245 out of 273) with the dominant NNRTI resistance mutations (E138A, K103N, E138Q, V179D) were found to belong to monophyletic clusters suggesting regional dispersal.
Abstract: The most frequently observed NNRTI resistant mutations were E138A (7.7%), E138Q (4.0%), K103N (2.3%) and V179D (1.3%).
Drug resistance mutation profiles of the drug-naive and first-line regimen-treated HIV-1-infected population of Suzhou, China.
Abstract: Only L76V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors.
Abstract: Six transmitted drug-resistant mutations were found, including two mutations (L33F and L76V) in the protease region and four (K70N/E and V179D/E) in the RT region.
HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China.
Abstract: M184V was the most frequently found point mutation, conferring resistance to the nucleoside reverse transcriptase inhibitor, while Y181C, G190A, K103N and V179D/E/F were the most frequent point mutations conferring resistance to the non-nucleoside reverse transcriptase inhibitor.
Result: In the mutations identified at time of diagnosis, A71T, A71AT, A71AV, V179D, V106I, V106EIKV are polymorphic mutations.
Result: We found that M184V was the
Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.
Method: Four subjects on ART also had viruses harboring the NNRTIs secondary mutations V179D, A98G, E138A, V179E, and F227L, including subject NA2CMR151 who had both A98G and the major NNRTI resistance mutation Y181C.
Transmission Dynamics of HIV-1 Drug Resistance among Treatment-Naive Individuals in Greece: The Added Value of Molecular Epidemiology to Public Health.
Introduction: Resistance to NNRTIs was the most prevalent (16.9%), and our previous analysis revealed that the majority (89%) of NNRTI-resistant viruses (E138A, K103N, and V179D) for subtype A1 belonged to monophyletic clusters (local transmission networks (LTNs)).
The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014.
Result: 31 specific DRMs were identified from 27 samples with DRMs distributing as: 1) 74.2% (23/31) DRMs were on nonnucleoside reverse transcriptase inhibitors (NNRTIs) as: V179E/D (n = 16), K238N (n = 2),
Table: V179D
Discussion: These two drugs were mostly adopted as first-line NNRTIs for anti-retrovirus treatment (ART) in China.While V179D and E138A mutations were described as polymorphic accessory NNRTI-selected mutation, however, it is unclear whether the V179D and E138A mutations have resulted from drug-specific or natural selective pressure by Chinese population.
HIV mutation literature information.
PMID: 
2018
BMC infectious diseases
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