Result: The largest PDR-related cluster within network contained DRM propagation of Discussion: Furthermore, it is worth noting that the DRM V179D/E associated with NNRTI was the most common, and spread widely within networks.
Discussion: Here, we found that sequences with V179D/E were distributed and networked among HETs, suggesting that V179D/E is involved in ongoing HIV-1 transmission in this region.
Discussion: Sharing of specific DRMs (such as V106I and V179D/E) was frequent within networks, revealing the potential for widespread PDR dissemination in the future.
Discussion: Studies have reported that V179D/E has been on the rise among the MSM population in recent years.
HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.
Result: Among them, 9 cases were protease inhibitor-related resistance, and the main resistance sites were L33F, V82A, Q58E, M46L, M46I; There were 4 cases of nucleoside reverse transcriptase inhibitor resistance, the main mutation sites were V75VI, K219Q, T215A, K65R; There were 5 cases of non-nucleoside reverse transcriptase inhibitor resistance, the main mutation sites were V179E, A98G, V106I,
Table: V179D
Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naive HIV Patients in Southeast China.
PMID: 33679129
2021
Drug design, development and therapy
Result: A total of 12 samples contained 13 NNRTIs-resistance mutations:V106I in 4 samples, V179E, V179D mutations each in 3 samples, E138A mutations in 2 samples and V106M in 1 sample.
Table: V179D
HIV Drug Resistance Mutations Detection by Next-Generation Sequencing during Antiretroviral Therapy Interruption in China.
Result: At baseline, mutations with a frequency of 20% and above were NRTI-related, such as M184VI (2.0%, 1/49), and NNRTI-related like K103N (14.3%, 7/49), E138AG (4.1%, 2/49), V179D (2.0%, 1/49) and P225H (2.0%, 1/49).
Result: The most common drug resistance mu
Discussion: Compared with the baseline, the HIVDR mutations, such as N88D, K65R, M184VI, K103N, E138AG, V179D and P225H, still existed but the frequency gradually decreased, consistent with earlier studies.
HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.
Result: Individuals infected with the subtypes CRF01_AE and CRF08_BC were the most likely to develop NNTRI-associated mutations; the most common mutations were V179E (7.21%), V179D (3.21%), and V106I (1.91%).
Discussion: Most V179E mutations were detected in CRF55_01B, and most V179D mutations were detected in CRF01_AE, CRF07_BC, and CRF08_BC subtypes.
Discussion: Mutations related to NNRTI resistance were common, especially V179E (7.21%) and V179D (3.21%).
Genetic Diversity, Complicated Recombination, and Deteriorating Drug Resistance Among HIV-1-Infected Individuals in Wuhan, China.
PMID: 32878449
2021
AIDS research and human retroviruses
Abstract: Among the 93 subjects of antiretroviral therapy (ART)-naive, transmitted drug resistance against non-nucleoside reverse transcriptase inhibitors (NNRTIs) was 23.9%, of which V179D/E was the most frequent mutation, accounting for 18.2%.
HIV Pretreatment Drug Resistance Trends in Mexico City, 2017-2020.
Result: However, other polymorphic non-SDRMs were also frequent (V106I (3.6%), V179DE (7.1%) in RT) (Figure 2b).
Natural polymorphisms in HIV-1 CRF01_AE strain and profile of acquired drug resistance mutations in a long-term combination treatment cohort in northeastern China.
Result: The NNRTI-associated DRMs detected at TF time point included G190S/C (66.7%), K101E/N/Q (52.4%), V179D/I/A/T/E (45.2%), Y181C (42.9%), K103R/N/S (42.9%), and V106 M (23.8%) (Table 1).
Table: V179D
Discussion: In this study, the polymorphisms at five known drug resistance-associated sites (V179I/D, V118I, K103R, K238R, and E40Q) were polymorphic accessory mutations or other mutations that did not independently decrease drug sensitivity.
HIV-1 subtypes and drug resistance mutations among female sex workers varied in different cities and regions of the Democratic Republic of Congo.
HIV mutation literature information.
PMID: 
2021
Frontiers in genetics
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