Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients.
Discussion: For instance, V118I has been identified in 2% of treatment-naive patients as one of strain-specific polymorphisms, but more frequently observed in RTI-treated patients.
The K65R mutation in HIV-1 reverse transcriptase: genetic barriers, resistance profile and clinical implications.
Introduction: The development of K65R and Q151M may be facilitated for HIV-2 variants originating from West Africa (Senegal and Portugal), harboring NNRTI mutations (K101A, V106I, V179I, Y181I, Y188L and G190A) and TAMs/NAMs (T69N, V75I, V118I, L210N, T215S and K219E) as natural polymorphisms.
Introduction: Two distinct TAM (TAM-1 and -2) pathways lead to the stepwise accumulation of major (M41L, K70R
Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon.
PMID: 18507527
2008
AIDS research and human retroviruses
Abstract: Mutations associated with nucleoside RT inhibitors (M184V in one case and V118I in four cases) were found in five samples, despite being derived from ARV-naive patients.
Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase.
Result: We also noted a positive association between K43E and amino acid changes E44A, V118I, H208Y, K219N/R and V75M (data not shown; p values were highly significant at an FDR level of 0.01 in all cases).
Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy.
Abstract: A large clinical database was queried to identify antiretroviral-naive patients with V118I as the sole resistance associated mutation.
Abstract: Although the V118I mutation in reverse transcriptase causes a reduced incorporation of zidovudine and lamivudine into transcribed viral DNA, it also decreases ATP-mediated pyrophosphorylysis.
Abstract: Furthermore, the presence of V118I as the sole nucleoside reverse transcriptase inhibitor mutation should not be over-interpreted when deciding on therapeutic options.
Abstract: Nevertheless, V118I remains identified as a resistance mutation by a number of commonly utilised resistance mutation algorithms.
Abstract: Our study suggests that V118I should be excluded from m
Prevalence and predictors of antiretroviral drug resistance in newly diagnosed HIV-1 infection.
PMID: 17213262
2007
The Journal of antimicrobial chemotherapy
Abstract: Resistance was scored according to the IAS-USA list (2005) modified to include T215revertants and exclude isolated E44D or V118I and minor protease mutations.
Molecular epidemiology and prevalence of drug resistance-associated mutations in newly diagnosed HIV-1 patients in Portugal.
PMID: 17360244
2007
Infection, genetics and evolution
Abstract: Mutations listed by the International AIDS Society-USA were considered, except E44D and V118I.
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.
Method: Recently described accessory NRTI mutations included T39A, K43E/Q/N, E44D/A, V118I, E203K, H208, D218E, H221Y, K223Q, and L228H/R.
Result: In addition to the five accessory mutations in Table 2 (K43E, E44D, V118I, H208Y, and D218E), other NRTI mutations that consistently followed TAMs included the known treatment-selected mutations T69D and
HIV mutation literature information.
PMID: 
2009
Antiviral research
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