literature

Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender, and age issues.

PMID: 21936717 2012 AIDS research and human retroviruses

Abstract: The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and

PMID: 22189822 2012 Archives of virology

Discussion: V118I is a polymorphism in non-B RT that is associated with subtype B NRTI resistance.

Discussion: One of the viruses harbored the combination V118I/E138A/V179D, while another had V118I/E138A.

Discussion: Other substitutions that were found include V90I, E138A, and V179D, which are weakly associated with decreased NNRTI susceptibility, and V118I, which occurs in ~2% of untreated individuals and with increased frequency in those receiving multiple NRTIs.

Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010.

PMID: 22593823 2012 AIDS research and treatment

Result: V118I was the third highest mutation for 2009 with an occurrence of 38 of 340 (11.2%).

Result: Statistically significant differences between men and women were observed for K70R (P = 0.04) and K219Q (P = 0.03) in 2006, K103N (P = 0.02) in 2007, K219E (P = 0.03) in 2009 (data not shown), and V118I (P = 0.03) in 2010.

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy.

PMID: 22889300 2012 Retrovirology

Abstract: Covariation of TAM1 mutations and V118I, V179I, M184V and R284K was observed.

Result: Amino acid substitutions D67N, L74I, K223E and L228H associate with the TAM2 cluster, while V118I, V179I, M184V and R284K are linked to cluster (2) formed by mutations of the TAM1 pathway.

Table: V118I

HIV-1 integrase resistance among antiretroviral treatment naive and experienced patients from Northwestern Poland.

PMID: 23259737 2012 BMC infectious diseases

Result: It must be noted, that three of the patients with developed drug resistance were heavily experienced with reverse transcriptase (RT) and protease (PR) mutations (patient 1: RT: M41L, K103N, M184V, T215S; PR: L10I; patient 2: PR: M41L, V118I, K103N, M184V, L210W, T215S, RT: L10I,

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.

PMID: 22889300 2012 Retrovirology

Result: M41L and T215Y were also strongly correlated with V118I (P < 10-6), and with accessory mutations Q174R and L228H.

New trends of primary drug resistance among HIV type 1-infected men who have sex with men in Liaoning Province, China.

PMID: 21417755 2011 AIDS research and human retroviruses

Abstract: L10I (4.5%), V118I/IV (17.4%), and K103R/KR (10.0%) were commonly observed mutations, but do not confer any drug resistance to PIs, NRTIs, and NNRTIs.

HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.

PMID: 21633285 2011 AIDS (London, England)

Result: Other NRTI-associated mutations detected included T69A/N/S (n=21), V75L, V118I and T215A/I.

Selection of HIV resistance associated with antiretroviral therapy initiated due to pregnancy and suspended postpartum.

PMID: 21765365 2011 Journal of acquired immune deficiency syndromes (1999)

Result: Several mutations associated with drug resistance that were not evaluated by OLA were detected by consensus sequencing, including M41L, V118I, E138A, and L210W.

Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.

PMID: 21297946 2011 PloS one

Method: The final list of mutations included M41L, E44D, D67N, T69D, K70R, L74V, L100I, K103N, V108I, V118I, Y181C, M184V, G190A, L210W, T215F, T215Y and K219Q in RT; and L33F, L33I, M46I, M46L, G48V, <