Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender, and age issues.
PMID: 21936717
2012
AIDS research and human retroviruses
Abstract: The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and PMID: 22189822
2012
Archives of virology
Discussion: V118I is a polymorphism in non-B RT that is associated with subtype B NRTI resistance.
Discussion: One of the viruses harbored the combination V118I/E138A/V179D, while another had V118I/E138A.
Discussion: Other substitutions that were found include V90I, E138A, and V179D, which are weakly associated with decreased NNRTI susceptibility, and V118I, which occurs in ~2% of untreated individuals and with increased frequency in those receiving multiple NRTIs.
Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010.
Result: V118I was the third highest mutation for 2009 with an occurrence of 38 of 340 (11.2%).
Result: Statistically significant differences between men and women were observed for K70R (P = 0.04) and K219Q (P = 0.03) in 2006, K103N (P = 0.02) in 2007, K219E (P = 0.03) in 2009 (data not shown), and V118I (P = 0.03) in 2010.
HIV-1 integrase resistance among antiretroviral treatment naive and experienced patients from Northwestern Poland.
Result: It must be noted, that three of the patients with developed drug resistance were heavily experienced with reverse transcriptase (RT) and protease (PR) mutations (patient 1: RT: M41L, K103N, M184V, T215S; PR: L10I; patient 2: PR: M41L, V118I, K103N, M184V, L210W, T215S, RT: L10I,
Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy.
Abstract: Covariation of TAM1 mutations and V118I, V179I, M184V and R284K was observed.
Result: M41L and T215Y were also strongly correlated with V118I (P < 10-6), and with accessory mutations Q174R and
Result: Amino acid substitutions D67N, L74I, K223E and L228H associate with the TAM2 cluster, while V118I, V179I, M184V and R284K are linked to cluster (2) formed by mutations of the TAM1 pathway.
New trends of primary drug resistance among HIV type 1-infected men who have sex with men in Liaoning Province, China.
PMID: 21417755
2011
AIDS research and human retroviruses
Abstract: L10I (4.5%), V118I/IV (17.4%), and K103R/KR (10.0%) were commonly observed mutations, but do not confer any drug resistance to PIs, NRTIs, and NNRTIs.
HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.
Result: Other NRTI-associated mutations detected included T69A/N/S (n=21), V75L, V118I and T215A/I.
Selection of HIV resistance associated with antiretroviral therapy initiated due to pregnancy and suspended postpartum.
PMID: 21765365
2011
Journal of acquired immune deficiency syndromes (1999)
Result: Several mutations associated with drug resistance that were not evaluated by OLA were detected by consensus sequencing, including M41L, V118I, E138A, and L210W.
Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.
Method: The final list of mutations included M41L, E44D, D67N, T69D, K70R, L74V, L100I, K103N, V108I, V118I, Y181C, M184V, G190A, L210W, T215F, T215Y and K219Q in RT; and L33F, L33I, M46I, M46L, G48V, <
Phenotypic analysis of HIV-1 genotypic drug-resistant isolates from China, using a single-cycle system.
HIV mutation literature information.
PMID: 
2012
AIDS research and human retroviruses
Browser Board
Co-occurred Entities
Filtrator
ViMRT