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 HIV mutation literature information.


  Clinically relevant genotype interpretation of resistance to didanosine.
 PMID: 15855490       2005       Antimicrobial agents and chemotherapy
Abstract: Eight mutations were associated with a reduced response to ddI, M41L, D67N, T69D, L74V, V118I, L210W, T215Y/F, and K219Q/E, and two mutations were associated with a better response, K70R and M184V/I.


  Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs.
 PMID: 19825125       2005       Journal of the International AIDS Society
Table: V118I


  Antiretroviral resistance and genetic diversity of human immunodeficiency virus type 1 isolates from the Federal District, Central Brazil.
 PMID: 15761606       2004       Memorias do Instituto Oswaldo Cruz
Abstract: Many mutations associated with reduced susceptibility to nucleoside or non-nucleoside reverse transcriptase inhibitors were detected: M41L (11%), E44D (4%), D67N (11%), T69D (2%), K70R (11%), L74V (2%), L100I (4%), K103N (18%), V118I (9%), Y181C (11%), M184V (18%), G190A (4%), T215Y (4%), and K219E (4%).


  Primary drug-resistance in HIV-positive patients on initiation of first-line antiretroviral therapy in Germany.
 PMID: 15257882       2004       European journal of medical research
Abstract: 10.5% showed mutations indicating nucleoside reverse transcriptase inhibitor- (NRTI) resistance (M41L, E44D, D67N, T69D/N, L74V, V118I, M184V, L210W, K219Q), 2.8% showed non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance (K103N, V108I, Y181C), and 2.1% showed protease-inhibitor- (PI) associated resistance (


  Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy.
 PMID: 15242545       2004       AIDS research and human retroviruses
Abstract: Analysis of the RT genes for resistance-associated substitutions revealed two sequences containing a V118I substitution.
Abstract: Even though no other resistance-associated substitutions were found, the presence of V118I, which is implicated in resistance to reverse transcriptase inhibitors, in CRF02_AG strains infecting drug-naive individuals should be considered when introducing these antiretrovirals in areas where CRF02_AG is the predominant subtype, such as Cameroon.


  Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy.
 PMID: 15000558       2004       Scandinavian journal of infectious diseases
Abstract: Only the V118I RT mutation was statistically more common among virologic failing than non-failing NRTI pretreated patients (p < 0.05).
Abstract: Stepwise multiple regression analysis for viral failure resulted in a model with only the V118I RT mutation entering the model (p < 0.01).
Abstract: The viral strains from the virologic failing patients harboured 3-6 reverse transcriptase (RT) mutations, including the V118I mutation in 5/6 cases prior to PI-ART or at viral rebound.


  Mutation patterns of the reverse transcriptase genes in HIV-1 infected patients receiving combinations of nucleoside and non nucleoside inhibitors.
 PMID: 14522102       2003       International journal of antimicrobial agents
Abstract: Among mutations correlated to high (K103N, V106A, Y181C/I, Y188C/H/L, G190A/C/E/Q/S/T) or moderate (V108I, V118I) levels of nevirapine resistance, the predominant amino acid change was a substitution at 103 codon, present in 24 of 80 samples tested.


  Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy.
 PMID: 12819190       2003       The Journal of biological chemistry
Abstract: Both mechanisms show a certain degree of incompatibility; however, previous clinical data revealed that mutations E44D and V118I, when present in a background of classical AZT mutations (M41L, D67N, L210W, and T215Y), confer dual resistance to AZT and 3TC.
Abstract: Our findings are consistent with an increasing number of clinical studies suggesting that the V118I cluster constitutes a novel pathway for HIV resistance to multiple nucleotide analogue RT inhibitors.
Abstract: The V118I mutant is also associated with diminished rates of ATP-dependent primer unblocking.


  Brazilian Network for HIV Drug Resistance Surveillance (HIV-BResNet): a survey of chronically infected individuals.
 PMID: 12700457       2003       AIDS (London, England)
Abstract: Mutations known to be associated with reduced sensitivity to NRTI or NNRTI (V118I, E44D, K219R, T69A, and V75L) were found in a low prevalence (0.6-2.4%).


  HIV-1 subtype C reverse transcriptase sequences from drug-naive pregnant women in South Africa.
 PMID: 12036490       2002       AIDS research and human retroviruses
Abstract: An additional three patients harbored V118I, which can function as an accessory resistance mutation, but in this context is also likely to be a polymorphism.



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