literature

HIV mutation literature information.

Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.

PMID: 11920313 2002 The Journal of infectious diseases

Abstract: As expected, E44A/D and V118I mutations were strongly associated with M41L, D67N, L210W, and T215Y but also with other mutations, including K43E/N/Q, T69D, V75M, H208Y, R211K, and K219R.

Abstract: Both E44D and V118I were more frequently associated with stavudine and didanosine than with zidovudine and lamivudine treatment.

Abstract: However, selection of E44A/D and V118I was also detected in associa

Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy.

PMID: 11793380 2002 Journal of medical virology

Abstract: A relationship was found between the E44D/A and/or V118I mutational pattern and experience with didanosine or stavudine but not with lamivudine.

Abstract: It has been reported that a new pattern of mutations, E44D/A and/or V118I, in the reverse transcriptase (RT) gene of HIV-1 confers a moderate level of resistance to lamivudine in the absence of the M184V mutation.

Abstract: Multivariate analysis showed an association between the E44D/A and/or V118I mutational pattern and the RT mutations D67N, T69D, L210W,

Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy.

PMID: 11181387 2001 Antimicrobial agents and chemotherapy

Abstract: Recently, it has been shown that a new mutational pattern (the E44D/A and/or V118I mutation) confers moderate phenotypic lamivudine resistance in the absence of the M184V mutation.

Abstract: The E44D/A and/or the V118I mutation does not exist in drug-naive patients, and the prevalence increases with the number of treatment regimens and lamivudine experience.

Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients.

PMID: 11737863 2001 BMC microbiology

Abstract: In particular, two mutations (K70R and V118I), detectable by LIPA and by sequencing analysis respectively, revealed resistance to NRTIs in two plasma samples.

Result: As expected, the presence of mutations associated with resistance to non nucleoside reverse transcriptase inhibitors (NNRTIs), only revealed by sequencing analysis showed VI 081 (associated with a reduced drug sensitivity to efavirenz plus nevirapine), V118I (associated with moderate phenotypic lamivudine resistance) and the presence of K103N (key mutation for all the NNRIs) plus Y181C (with variable effects on susceptibility to efavirenz, besides resistance to nevirapine).

Browser Board

Co-occurred Entities

Filtrator