Result: Compared to patients in the NVP group (n = 8), patients under EFV pressure (n = 40) were 3.5 times more likely to present with a V106M mutation (aRR 3.53 95% CI 1.77-7.05.
Table: V106M
Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.
Result: The most prevalent NNRTI mutations were Y181C/I/V (n = 24, 35%), (n = 3, 4%), and (n = 1 (1%), respectively, K103N/S (n = 21 (32%) and n = 1 [1%]), G190A/S/E (n = 20 (29%), n = 1 (1%), and (n = 2, 3%), respectively, V108I (n = 13, 19%), and V106A/M (n = 2, 3%) and (n = 10, 15%).
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
Result: V106M accounted for a higher proportion of genotypic NNRTI SDRMs in subtype C viruses than in pooled viruses belonging to the remaining subtypes (5% versus 1%; eight of 179 versus ten of 1,567; p < 0.001).
Single Genome Analysis for the Detection of Linked Multiclass Drug Resistance Mutations in HIV-1-Infected Children After Failure of Protease Inhibitor-Based First-Line Therapy.
PMID: 25923117
2015
Journal of acquired immune deficiency syndromes (1999)
5Result: More than 1 RT DRM linked on the same genome were detected in 2 children: in ""J,"" Y181C was linked with V106M (2%, n = 49 sequences) and K219N (2%); in ""E,"" Y181C linked with the accessory TAM, K219N, was detected (3%, n = 30 sequences) and linked dual-class resistance (Y181C with L74V) was also detected (7%) in the baseline viral population of this child."
Result: Bulk sequence analyses detected baseline NVP-selected resistance in 5 of 10 children: K103N, V106M, and Y188C in 1 child each and Y181C in 2 children.
Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
Result: It is noteworthy that several major mutations associated to high level resistance to NRTIs (K65R, L74V, Y115F, M184V and T215Y), to NNRTIs (l100I, K101E, K103N/S, V106M, Y181C, Y188L and G190A) and to PIs (D30N, M46I/L, I54V/T, L76V, V82A, I84V, N88D
Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique.
Method: A NVP RAM was considered if at least one of the following genetic changes in reverse transcriptase was detected: A98G, K101E, K101H, K101P, K103N, V106A, V106M, V108I, Y181C, Y181V, Y188L and G190A.
Result: The mutations K101H, V106M, Y181V and Y188L were found in only one sample each (Fig 2).
Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.
Result: Twenty-eight NVP-selected mutations (V90I, K101E, K103N/R, V106A/I/M, V108I, E138A/G/K/R, Y181C, Y188C, G190A or P225H) were detected in 19 samples at levels of 1.1% to 99.1%.
Table: V106M
Low Incidence of HIV-1C Acquired Drug Resistance 10 Years after Roll-Out of Antiretroviral Therapy in Ethiopia: A Prospective Cohort Study.
Abstract: The NNRTIs resistance associated mutations were K103N (n = 2), V106M, Y181S, Y188L, V90I, K101E and G190A (n = 1 each).
Result: The NNRTIs resistance associated mutations V106M a
Table: V106M
Discussion: Among the NNRTIs mutations, K103N, V106M, and G190A conferring resistance to EFV and NVP; EFV, NVP and ETR; and EFV and NVP, respectively were observed in 2 and 1 patient each similar to recent data from various African countries.
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
HIV mutation literature information.
PMID: 
2015
AIDS research and human retroviruses
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