Abstract: The most common DRMs were; M184V (51.7%), K103N (50%), V106M (20.6%), D67N (13.3%), K65R (12%).
Introduction: Specifically, V106M (NNRTI), K65R (NRTI) and N348I are more common among subtype C strains compared to other group M strains.
Discussion: In addition, the high levels of V106M mutations could also be attributed to subtype-specificity, since this mutation had been found most frequently among subtype C.
Discussion: Our study confirmed the dominance of K65R and V106M, two mutations which are most common
HIV-1 viraemia and drug resistance amongst female sex workers in Soweto, South Africa: A cross sectional study.
Result: Amongst treatment defaulters (n = 5), 4 had the K103N mutation and 1 had the V106M mutation.
Result: For those on treatment (n = 14), 7 had the K103N mutations and 5 had the V106M or G190A mutations, and 2 and the K101E mutations.
Result: Overall, the number of FSWs with the K103N mutation was 68.9% (31/45), the K101E mutation was found in 6/45 (13.3%), the V106M mutation in 10/45 (22.2%), G190A in 5/45 (11.1%), and the NRTI mutation M184V was present in 13/45 (28.9%) of SWs.
Table: V106M
Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Abstract: The observed mutations for NRTI were K65R, T215I and K219E (33.0% each) and for NNRTI: V106M, Y181C and Y188H (6.0% each).
Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.
Method: Analysis of pol sequences showed that 11 of these 32 subjects (34.3%) were infected with viruses harboring major DRMs, including major resistance mutations to NRTIs such as D67N, K70R, M184V, K219Q/E, T215F, and T69N; and major resistance mutations to NNRTIs such as Y181C, K103N, V106A/M, P225H, Y188L, H221Y,
Table: V106M/A
Table: V106M
Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa.
PMID: 28981637
2017
The Journal of antimicrobial chemotherapy
Abstract: DRMs were detected in 89% of 123 specimens with VF, including M184I/V, K103N/S, K65N/R, V106A/M and Y181C.
Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.
Abstract: The most frequent NNRTIs associated mutations were K103N, V106M and Y188C.
Result: At T1, the NNRTIs resistance associated mutations were detected at a lower frequency [K103N (n = 2), V106M, Y181S, Y188L, V90I, K101E and G190A (n = 1 each)].
Table: V106M
Discussion: Lastly, the study in one side identified an increasing common mutational pathways overtime with two thymidine non-analog (M184V and K65R) and three thymidine analog (
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naive and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes.
Discussion: These two ARV drugs are administered alternatively when K103N, V106A/M and P225H are already expressed, as these mutations are not selected by these drugs.
Increasing HIV-1 Drug Resistance Between 2010 and 2012 in Adults Participating in Population-Based HIV Surveillance in Rural KwaZulu-Natal, South Africa.
PMID: 27002368
2016
AIDS research and human retroviruses
Result: Of these, the most common were K103N, V106M, and G190A occurring in 27 (3.9%), 3 (0.4%), and 2 (0.3%) participants, respectively.
Result: Twelve of the 15 had a single NNRTI mutation (10 with K103N, 1 with V106M, and 1 with G190A) (Supplementary Table S1.
HIV mutation literature information.
PMID: 
2017
PloS one
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